多糖在纳米药物表面修饰中的应用。
Application of polysaccharides for surface modification of nanomedicines.
作者信息
Doh Kyung-Oh, Yeo Yoon
机构信息
Department of Physiology, Yeungnam University, Daegu, Republic of Korea.
出版信息
Ther Deliv. 2012 Dec;3(12):1447-56. doi: 10.4155/tde.12.105.
Abstract
Polysaccharides have been used in various biomedical applications due to availability and biocompatibility. In particular, polysaccharides have gained increasing interest in the development of functional nanomedicines as a component to provide a stealth function, improve interactions with target tissues or enable environment-responsive drug release. This review discusses recent advances in nanomedicine engineering based on polysaccharides with a specific emphasis on the rationale, applications and the remaining challenges.
摘要
由于多糖易于获取且具有生物相容性，因此已被应用于各种生物医学领域。特别是，多糖作为提供隐身功能、改善与靶组织相互作用或实现环境响应性药物释放的成分，在功能性纳米药物的开发中越来越受到关注。本文综述了基于多糖的纳米医学工程的最新进展，特别强调了其原理、应用和尚存的挑战。
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