Silva Amanda Karine Andriola, Letourneur Didier, Chauvierre Cédric
Inserm, U698, Cardiovascular Bio-Engineering; X. Bichat hospital, 46 rue H. Huchard, F-75018, Paris, France; Université Paris 13, Sorbonne Paris Cité, F-93430, Villetaneuse, France.
Theranostics. 2014 Mar 11;4(6):579-91. doi: 10.7150/thno.7688. eCollection 2014.
Natural polysaccharides have received a lot of attention in the biomedical field. Indeed, sources of polysaccharides, extracted or produced from plants, bacteria, fungi or algae, are diverse and renewable. Moreover, recent progresses in polysaccharide chemistry and nanotechnologies allow elaborating new dedicated nanosystems. Polysaccharide-based nanosystems may be designed for interacting in several biological processes. In particular, the atherothrombotic pathology is highly concerned by polysaccharide-mediated recognition. Atherothrombotic diseases, regardless of the anatomical localization, remain the main causes of morbidity and mortality in the industrialized world. This review intends to provide an overview on polysaccharide-based nanosystems as drug delivery systems and targeted contrast agents for molecular imaging with an emphasis on the treatment and imaging of cardiovascular pathologies.
天然多糖在生物医学领域受到了广泛关注。事实上，从植物、细菌、真菌或藻类中提取或生产的多糖来源多样且可再生。此外，多糖化学和纳米技术的最新进展使得能够构建新的专用纳米系统。基于多糖的纳米系统可设计用于参与多种生物过程。特别是，动脉粥样硬化血栓形成病理学与多糖介导的识别密切相关。动脉粥样硬化血栓形成疾病，无论其解剖学定位如何，仍然是工业化世界中发病和死亡的主要原因。本综述旨在概述基于多糖的纳米系统作为药物递送系统和分子成像的靶向造影剂，重点关注心血管疾病的治疗和成像。
