Soll M D, Carmichael I H, Swan G E, Abrey A
Merck Sharp & Dohme Research Laboratories, Rahway, NJ 07065.
Vet Rec. 1992 Jun 27;130(26):572-4. doi: 10.1136/vr.130.26.572.
Four trials including 11,266 sheep were conducted in South Africa to evaluate the efficacy of the systemic parasiticide ivermectin against field outbreaks of sheep scab (Psoroptes ovis) when two doses of approximately 200 micrograms/kg were administered subcutaneously seven days apart (days 0 and 7). As sheep scab is a notifiable disease in South Africa, it was not possible to include an untreated control group. The prevalence of clinically affected animals in the four treated flocks varied from 0.4 per cent to 99 per cent before the two treatments. After the treatments, there were no signs of active clinical infection in any of the sheep between days 28 and 30, or at subsequent examinations. P ovis mites were recovered from scrapings from 114 of 127 indicator sheep before the treatment but no mites were recovered from them between days 28 and 30 or 42 and 58 after the treatments.
在南非进行了四项试验，涉及11266只绵羊，以评估全身性杀寄生虫药伊维菌素对绵羊疥癣（痒螨）田间疫情的疗效。试验中，每隔七天（第0天和第7天）皮下注射两剂约200微克/千克的伊维菌素。由于绵羊疥癣在南非属于应通报疾病，因此无法设置未治疗的对照组。在两次治疗前，四个接受治疗的羊群中临床受影响动物的患病率在0.4%至99%之间。治疗后，在第28天至30天期间以及随后的检查中，任何绵羊均未出现活动性临床感染迹象。治疗前，从127只指示羊的刮片中检出114只痒螨，但在治疗后的第28天至30天或第42天至58天期间，未从这些羊中检出螨。
