Podvigina T T, Bagaeva T R, Filaretova L P, Pykholov A A
Laboratory of Experimental Endocrinology, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia.
Bull Exp Biol Med. 2003 Nov;136(5):435-7. doi: 10.1023/b:bebm.0000017085.18950.87.
We studied the effects of adrenalectomy and replacement therapy on healing of gastric erosions in adult Sprague-Dawley rats developed 4 h after subcutaneous injection of indomethacin in a dose of 25 or 35 mg/kg. Adrenalectomy was performed 1 week before or 4 h after indomethacin administration. Healing was evaluated by changes in the area of erosions over 24 h after indomethacin administration at fixed time intervals. Plasma corticosterone was measured. Adrenalectomy (irrespective of the time of intervention) decelerated healing of gastric injuries. Injection of corticosterone in a physiological dose of 4 mg/kg at the initial stage of healing (4 h after indomethacin administration) improved healing of erosions.
我们研究了肾上腺切除术及替代疗法对成年斯普拉格-道利大鼠胃糜烂愈合的影响，这些大鼠在皮下注射剂量为25或35mg/kg的吲哚美辛4小时后形成胃糜烂。肾上腺切除术在吲哚美辛给药前1周或给药后4小时进行。通过在吲哚美辛给药后固定时间间隔的24小时内观察糜烂面积的变化来评估愈合情况。测定血浆皮质酮水平。肾上腺切除术（无论干预时间如何）都会延缓胃损伤的愈合。在愈合初期（吲哚美辛给药后4小时）注射生理剂量4mg/kg的皮质酮可改善糜烂的愈合。
