Clemens M R, Müller-Ladner C I, Gey K F
Eberhard-Karls-Universität Tübingen, Medizinische Klinik und Poliklinik, Abteilung Innere Medizin II, Bundesrepublik Deutschland.
Z Ernahrungswiss. 1992 Jun;31(2):110-20. doi: 10.1007/BF01623069.
Plasma from 22 patients was examined for alpha- and gamma-tocopherol (vitamin E), the carotenoids beta-carotene (provitamin A) and lycopene, retinol (vitamin A), and ascorbic acid (vitamin C) before, during and after conditioning chemotherapy for bone marrow transplantation, 18 of these received total body irradiation as well. In addition, alpha-tocopherol in red blood cell membranes was measured. Retinol and ascorbic acid have been applied in multiple of the recommended doses (Deutsche Gesellschaft für Ernährung and Recommended Dietary Allowance, respectively). The chosen doses were sufficient to maintain the initial plasma concentrations of these vitamins. However, alpha-tocopherol (in RDA doses) and beta-carotene (no RDA established) concentrations deteriorated after the conditioning therapy (20 and 50% loss, respectively). The loss of these lipid-soluble antioxidants has been considered to result from lipid peroxidation. On the basis of the presented results we propose intervention studies to investigate the effect of high dose antioxidant administration on the toxicity (mainly of liver and lung) of intensive antineoplastic therapy protocols.
对22例患者的血浆进行了检测，以测定其α-生育酚和γ-生育酚（维生素E）、类胡萝卜素β-胡萝卜素（维生素A原）和番茄红素、视黄醇（维生素A）以及抗坏血酸（维生素C）的含量，检测时间为骨髓移植预处理化疗前、化疗期间及化疗后，其中18例患者还接受了全身照射。此外，还测定了红细胞膜中的α-生育酚含量。视黄醇和抗坏血酸的应用剂量分别为推荐剂量的数倍（分别参照德国营养学会标准和推荐膳食摄入量标准）。所选剂量足以维持这些维生素的初始血浆浓度。然而，预处理化疗后，α-生育酚（按推荐膳食摄入量标准剂量）和β-胡萝卜素（未确立推荐膳食摄入量标准）的浓度下降（分别下降了20%和50%）。这些脂溶性抗氧化剂的损失被认为是脂质过氧化作用所致。基于所呈现的结果，我们建议开展干预研究，以探究大剂量抗氧化剂给药对强化抗肿瘤治疗方案毒性（主要是肝脏和肺部毒性）的影响。
