Quinn M A, Emery P
Academic Unit of Musculoskeletal Disease, Department of Rheumatology, Leeds General Infirmary, Leeds, United Kingdom.
Clin Exp Rheumatol. 2003 Sep-Oct;21(5 Suppl 31):S154-7.
Therapeutic strategies for the treatment of rheumatoid arthritis (RA) have changed significantly in the last decade. The emphasis is now on early intervention with the aim of preventing disability and irreversible damage. Advocates of early intervention would suggest an alteration in the disease process, not just debulking of inflammatory disease. The data would at least support attenuation of the disease process with aggressive early therapy. Further research is required to elucidate the scientific mechanisms involved and their impact on the pathological progress of RA.
在过去十年中，类风湿关节炎（RA）的治疗策略发生了显著变化。现在的重点是早期干预，目标是预防残疾和不可逆损伤。早期干预的支持者认为这会改变疾病进程，而不仅仅是减轻炎症性疾病。现有数据至少支持积极的早期治疗可减缓疾病进程。还需要进一步研究以阐明其中涉及的科学机制及其对RA病理进展的影响。
