Mroczko Barbara, Ławicki Slawomir, Szmitkowski Maciej, Czygier Małgorzata, Okulczyk Bogna, Piotrowski Zdzisław
Zakład Diagnostyki Biochemicznej Akademii Medycznej w Białymstoku.
Pol Merkur Lekarski. 2003 Nov;15(89):416-9.
We have investigated the serum level of selected hematopoietic cytokines, such as interleukin 3, granulocyte-macrophage--colony stimulating factor (GM-CSF), granulocyte--colony stimulating factor (G-CSF) and macrophage--colony stimulating factor (M-CSF) in colorectal cancer patients. Also correlations between their concentrations and stages were made. The study was done on group consisted of 30 diagnosed colorectal cancer patients. The used classification of stage of the tumor was described by Dukes. The results were compared with control group consisted of 20 healthy persons. The examined factors were assayed by ELISA method. In colorectal cancer patients the serum levels of IL-3, GM-CSF and M-CSF were increased in comparison with the control group. The differences between cytokines concentrations in control group and colorectal cancer patients were statistically significant for GM-CSF and M-CSF. The serum levels of cytokines were higher in more advanced tumor stage. This results permit for further study on usefulness of these cytokines as a markers for colorectal cancer.
我们研究了结肠癌患者血清中某些造血细胞因子的水平，如白细胞介素3、粒细胞-巨噬细胞集落刺激因子（GM-CSF）、粒细胞集落刺激因子（G-CSF）和巨噬细胞集落刺激因子（M-CSF）。还分析了它们的浓度与肿瘤分期之间的相关性。该研究针对30例确诊的结肠癌患者进行。肿瘤分期采用Dukes分类法。结果与由20名健康人组成的对照组进行比较。所检测的因子采用ELISA法测定。与对照组相比，结肠癌患者血清中IL-3、GM-CSF和M-CSF水平升高。GM-CSF和M-CSF在对照组和结肠癌患者中的细胞因子浓度差异具有统计学意义。在肿瘤分期越晚的患者中，细胞因子的血清水平越高。这些结果为进一步研究这些细胞因子作为结肠癌标志物的实用性提供了依据。
