Demirayak Seref, Karaburun Ahmet Cagri, Kayagil Ismail, Erol Kevser, Sirmagul Basar
Dept. of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Anadolu, Eskisehir, Turkey.
Arch Pharm Res. 2004 Jan;27(1):13-8. doi: 10.1007/BF02980038.
In this study, 6-[(4-arylidene-2-phenyl-5-oxoimidazolin-1-yl)phenyl]-4,5-dihydro-3(2H)-pyridazinone and 4-[(4-arylidene-2-phenyl-5-oxoimidazolin-1-yl)phenyl]-1(2H)-phthalazinone derivatives were synthesized by reacting 6-(4-aminophenyl)-4,5-dihydro-3(2H)-pyridazinone or 4-(4-aminophenyl)-1(2H)-phthalazinone compound with different 4-arylidene-2-phenyl-5(4H)-oxazolone derivatives. The vasodilator activities of the compounds were examined both in vitro and in vivo. Some pyridazinone derivatives showed appreciable activity.
在本研究中，通过使6-(4-氨基苯基)-4,5-二氢-3(2H)-哒嗪酮或4-(4-氨基苯基)-1(2H)-酞嗪酮化合物与不同的4-亚芳基-2-苯基-5(4H)-恶唑酮衍生物反应，合成了6-[(4-亚芳基-2-苯基-5-氧代咪唑啉-1-基)苯基]-4,5-二氢-3(2H)-哒嗪酮和4-[(4-亚芳基-2-苯基-5-氧代咪唑啉-1-基)苯基]-1(2H)-酞嗪酮衍生物。对这些化合物的血管舒张活性进行了体外和体内研究。一些哒嗪酮衍生物显示出可观的活性。
