哒嗪酮衍生物的合成、表征及抗高血压活性。
Synthesis, characterization and antihypertensive activity of pyridazinone derivatives.
机构信息
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi-110062, India.
出版信息
Eur J Med Chem. 2010 Jun;45(6):2283-90. doi: 10.1016/j.ejmech.2010.02.003. Epub 2010 Feb 6.
Some 6-(substituted-phenyl)-2-(substitutedmethyl)-4,5-dihydropyridazin-3(2H)-one derivatives were synthesized by reacting 6-substituted-phenyl-4,5-dihydropyridazin-3(2H)-one with cyclic secondary amine under Mannich reaction conditions. The final compounds (15-70) were evaluated for antihypertensive activities by non-invasive method using Tail Cuff method. The compounds 16, 19, 24, 30, 39, 42 and 45 showed good antihypertensive activity.
一些 6-(取代苯基)-2-(取代甲基)-4,5-二氢哒嗪-3(2H)-酮衍生物是通过在曼尼希反应条件下使 6-取代苯基-4,5-二氢哒嗪-3(2H)-酮与环状仲胺反应合成的。最终的化合物（15-70）通过使用尾套法的无创方法进行了抗高血压活性评估。化合物 16、19、24、30、39、42 和 45 表现出良好的抗高血压活性。
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