Ehrhardt Carsten, Kneuer Carsten, Bakowsky Udo
Department of Biopharmaceutics and Pharmaceutical Technology, Saarland University, Building 8.1, 66123 Saarbrücken, Germany.
Adv Drug Deliv Rev. 2004 Mar 3;56(4):527-49. doi: 10.1016/j.addr.2003.10.029.
Selectins are multifunctional adhesion molecules that mediate the initial interactions between circulating leukocytes and cells of the endothelium. First identified over a decade ago, selectins have provided insight into areas as diverse as normal lymphocyte homing, leukocyte recruitment during inflammatory responses, carbohydrate ligand biosynthesis and adhesion-mediated signalling. Of late, selectins were introduced as targets for drug delivery in the development of new anti-inflammatory therapeutics and in anti-cancer therapy. This review will examine the selectins and their ligands with a focus on recent findings on their role in physiology and pathophysiology as well as the emerging role of selectins as targets in controlled drug delivery.
选择素是多功能粘附分子，介导循环白细胞与内皮细胞之间的初始相互作用。选择素在十多年前首次被发现，它为多个领域提供了深入见解，如正常淋巴细胞归巢、炎症反应期间白细胞募集、碳水化合物配体生物合成以及粘附介导的信号传导。最近，选择素被引入作为新型抗炎治疗药物和抗癌治疗药物递送的靶点。本综述将研究选择素及其配体，重点关注它们在生理和病理生理中的作用的最新发现，以及选择素作为可控药物递送靶点的新作用。
