Witz Isaac P
Department of Cell Research and Immunology, Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel.
Immunol Lett. 2006 Apr 15;104(1-2):89-93. doi: 10.1016/j.imlet.2005.11.008. Epub 2005 Dec 6.
About 70 years ago, Peyton Rous described the progression of cancer towards metastasis formation as "the process whereby tumors go from bad to worse". The interactions of tumor cells with endothelium are pivotal steps in this process. This review focuses on the role played by the selectins and their ligands in these interactions and especially in tumor cell extravasation. The working hypothesis of researchers studying tumor cell extravasation is that the tumor cells follow the extravasation strategy of leukocytes in their migration towards inflammatory sites. A significant portion of this review is, therefore, dedicated to the molecular mechanisms underlying leukocyte extravasation and to a comparison between the extravasation strategy employed by leukocytes and tumor cells. The review also summarizes some of the available data on signals generated by selectin-selectin ligand interactions.
大约70年前，佩顿·劳斯将癌症向转移形成的进展描述为“肿瘤从恶变到更糟的过程”。肿瘤细胞与内皮细胞的相互作用是这一过程中的关键步骤。本综述重点关注选择素及其配体在这些相互作用中，特别是在肿瘤细胞外渗中所起的作用。研究肿瘤细胞外渗的研究人员的工作假设是，肿瘤细胞在向炎症部位迁移时遵循白细胞的外渗策略。因此，本综述的很大一部分致力于白细胞外渗的分子机制以及白细胞和肿瘤细胞所采用的外渗策略之间的比较。该综述还总结了一些关于选择素-选择素配体相互作用产生的信号的现有数据。
