[Chemical constituents from Chinese marine sponge Cinachyrella australiensis].

OBJECTIVE

To investigate the secondary metabolites from Chinese marine Sponge Cinachyrella australiensis.

METHODS

Column chromatography techniques including HPLC were used for the separation and purification of the compounds, and extensive spectral analyses including various 2D NMR spectra were employed for structure elucidation.

RESULTS

Nineteen compounds were obtained,including 2-methyoxy-6,12,15-trien-8-yne-octadecanoic acid (1), 2-benzenedicarboxylic acid dibutyl ester(2), 1,2-benzenedicarboxylic acid bis(2-ethylhexyl)ester(3), (-) (3S)-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid(4), L-Tryptophan (5), p-hydroxylbenzaldehyde (6), p-hydroxyl-benzylethanol(7), p-hydroxyl-benzyl-propanol(8), cholesta-4-en-3-ol(9), 2-methyl-6-amino-9-(2-deoxy-beta-D- ribofuranosyl-purine(10), 2'-Deoxyadenosine (11), 6-amino-9-beta-D-ribofuranosyl-9H-purine (12),uracil(13), thymine(14), thymidine(15), 1-(2-deoxy-beta-D-Ribofuranosyl) uracil(16), 1-ethyl-alpha-(2-deoxy)-beta-D-ribofuranos(17),isolumichrome(18),and zarzissine(19).

CONCLUSION

Compounds 1 and 18 are new natural products,and compounds 2 to 17 as well as 19 are isolated from this species for the first time.