König G M, Wright A D, Linden A
Institute for Pharmaceutical Biology, Technical University Braunschweig, Germany.
Planta Med. 1998 Jun;64(5):443-7. doi: 10.1055/s-2006-957477.
From a Maltese sample of the marine sponge Agelas oroides, five compounds: oroidin (1), 2-cyano-4,5-dibromopyrrole (2), 4,5-dibromopyrrole-2-carboxylic acid (3), 4,5-dibromopyrrole-2-carboxylic acid methyl ester (4), and 4 alpha-methyl-5 alpha-cholest-8-en-3 beta-ol (5) have been isolated. For compounds 1-5, completely assigned 1H- and 13C-NMR data are reported for the first time. For 2 a single crystal X-ray crystallographic analysis proved its structure unambiguously. The X-ray analysis of 2 indicated it to crystallise in an unexpected polar space group. Biological activity assessment of all isolates indicate 5 to have moderate antiplasmodial activity, as well as being cytotoxic, and 2 to be moderately cytotoxic towards several cancer cell lines.
从海洋海绵奥氏艾格海绵的一个马耳他样本中，分离出了五种化合物：奥洛定（1）、2-氰基-4,5-二溴吡咯（2）、4,5-二溴吡咯-2-羧酸（3）、4,5-二溴吡咯-2-羧酸甲酯（4）和4α-甲基-5α-胆甾-8-烯-3β-醇（5）。对于化合物1 - 5，首次报道了完全归属的1H和13C核磁共振数据。对于化合物2，单晶X射线晶体学分析明确证实了其结构。化合物2的X射线分析表明它结晶于一个意想不到的极性空间群。对所有分离物的生物活性评估表明，化合物5具有中等抗疟活性，同时具有细胞毒性，化合物2对几种癌细胞系具有中等细胞毒性。
