[Express of plasma ROS, SOD and GSH-PX in patients with nasopharyngeal carcinoma].

OBJECTIVE

To investigate the levels of plasma reactive oxygen species(ROS), superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) in patients with nasopharyngeal carcinoma (NPC) and to observe the state of metabolism of free radical in patients with NPC and the effects of them on nasopharyngeal carcinoma.

METHOD

The levels of plasma ROS, SOD and GSH-PX in 40 patients with NPC and 20 normal controls were identified by Fenton reaction method, xanthine oxidase method and dithiocarbamate method respectively.

RESULT

Plasma ROS activity[(11,327.835 +/- 483.777)/(U.ml-1)] in NPC increased significantly in comparison with the control group [(10,262.712 +/- 525.287)/(U.ml-1)] (P < 0.05). Plasma SOD and GSH-PX activities [(76.619 +/- 22.283)/(NU.ml-1), (98.653 +/- 46.374)/AU] in NPC decreased significantly in comparison with the control group [(154.603 +/- 27.241)/(NU.ml-1), (307.872 +/- 116.275)/AU] (P < 0.05). But there was no significant difference of the levels of plasma ROS[(10,987.235 +/- 469.340)/(U.ml-1), (10,081.53 +/- 488.409)/(U.ml-1), (12,085.044 +/- 564.721)/(U.ml-1)], SOD[(79.517 +/- 20.368)/(NU.ml-1), (67.975 +/- 24.202)/(NU.ml-1), (58.692 +/- 29.946)/(NU.ml-1)] and GSH-PX[(101.362 +/- 59.859)/AU, (89.338 +/- 42.259)/AU, (101.890 +/- 33.559)/AU] in different pathological kinds of NPC.

CONCLUSION

The metabolism of free radical is disturbed and the ability of anti-oxidation injury decreases significantly in patients with NPC, so anti-oxidation treatment should be given to suppress the development of NPC.