Zhang Ming, Liu Lisi, Cheng Lei, Zhang Ping
Department of Otorhinolaryngology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030.
Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2003 Nov;17(11):650-1.
To investigate the levels of plasma reactive oxygen species(ROS), superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) in patients with nasopharyngeal carcinoma (NPC) and to observe the state of metabolism of free radical in patients with NPC and the effects of them on nasopharyngeal carcinoma.
The levels of plasma ROS, SOD and GSH-PX in 40 patients with NPC and 20 normal controls were identified by Fenton reaction method, xanthine oxidase method and dithiocarbamate method respectively.
Plasma ROS activity[(11,327.835 +/- 483.777)/(U.ml-1)] in NPC increased significantly in comparison with the control group [(10,262.712 +/- 525.287)/(U.ml-1)] (P < 0.05). Plasma SOD and GSH-PX activities [(76.619 +/- 22.283)/(NU.ml-1), (98.653 +/- 46.374)/AU] in NPC decreased significantly in comparison with the control group [(154.603 +/- 27.241)/(NU.ml-1), (307.872 +/- 116.275)/AU] (P < 0.05). But there was no significant difference of the levels of plasma ROS[(10,987.235 +/- 469.340)/(U.ml-1), (10,081.53 +/- 488.409)/(U.ml-1), (12,085.044 +/- 564.721)/(U.ml-1)], SOD[(79.517 +/- 20.368)/(NU.ml-1), (67.975 +/- 24.202)/(NU.ml-1), (58.692 +/- 29.946)/(NU.ml-1)] and GSH-PX[(101.362 +/- 59.859)/AU, (89.338 +/- 42.259)/AU, (101.890 +/- 33.559)/AU] in different pathological kinds of NPC.
The metabolism of free radical is disturbed and the ability of anti-oxidation injury decreases significantly in patients with NPC, so anti-oxidation treatment should be given to suppress the development of NPC.
