遗传分析研讨会II：纳入连锁不平衡参数的结果

Genetic Analysis Workshop II: results of incorporating a linkage disequilibrium parameter.

作者信息

Goldgar D E, Fain P R

机构信息

Genetics Division, Boys Town National Institute, Omaha, NE.

出版信息

Genet Epidemiol. 1984;1(2):179-82. doi: 10.1002/gepi.1370010211.

DOI:10.1002/gepi.1370010211

PMID:14971367

Abstract

The corporation of a linkage disequilibrium parameter, delta, into linkage analysis is illustrated for data from Genetic Analysis Workshop II. Points from a joint likelihood surface are calculated and displayed on a recombination fraction-linkage disequilibrium grid using a simple modification of LIPED. The approach is shown to increase the power of linkage analysis and the power of tests for heterogeneity of linkage for the simulated examples.

摘要

针对遗传分析研讨会II的数据，展示了将连锁不平衡参数delta纳入连锁分析的过程。利用对LIPED的简单修改，计算联合似然表面的点，并将其显示在重组率-连锁不平衡网格上。对于模拟示例，该方法显示出可提高连锁分析的效能以及连锁异质性检验的效能。