遗传分析研讨会二：对问题3中分离分析和连锁分析的进一步思考。

Genetic Analysis Workshop II: further consideration of segregation and linkage analyses in Problem 3.

作者信息

Kramer P L, Altmann D B, Kidd K K

机构信息

Department of Human Genetics, Yale Univeristy School of Medicine, New Haven , Connecticut.

出版信息

Genet Epidemiol. 1984;1(2):189-93. doi: 10.1002/gepi.1370010213.

DOI:10.1002/gepi.1370010213

PMID:14971372

Abstract

We analyzed disease-marker associations in Problem 3 for the Genetic Analysis Workshop II, using PAP for segregation analysis and LIPED for linkage analysis. In this report we present aspects of our analyses that are not reported in the summary [MacCluer et al, 1984]. Certain features that we added to the running of LIPED to facilitate the analysis are discussed. Furthermore, we tested for Mendelian transmission in the hypothetical trait locus and we calculated modified relative risks for marker-trait genotypes. Some of the problems involved in analyzing complex associations among loci are discussed.

摘要

我们使用PAP进行分离分析，LIPED进行连锁分析，对遗传分析研讨会II的问题3中的疾病标记关联进行了分析。在本报告中，我们展示了分析中未在总结报告[MacCluer等人，1984年]中报告的方面。讨论了我们在运行LIPED时为便于分析而添加的某些特征。此外，我们在假设的性状位点测试了孟德尔传递，并计算了标记-性状基因型的修正相对风险。还讨论了分析基因座间复杂关联时涉及的一些问题。