Manju V, Balasubramanian V, Nalini N
Department of Biochemistry, Annamalai University, Tamilnadu, India.
J Biochem Mol Biol Biophys. 2002 Dec;6(6):387-90. doi: 10.1080/1025814021000036115.
Cervical carcinoma is the second most common cancer worldwide. The extent of free radical induced oxidative stress can be exacerbated by the decreased efficiency of antioxidant defense mechanisms. Low levels of essential antioxidants in the circulation have been found to be associated with an increased risk of cancer. The aim of our study was to assess the extent of oxidative stress, the levels of antioxidants like superoxide dismutase (SOD), catalase (CAT), ceruloplasmin and to evaluate tumor markers such as aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP) and total sialic acid (TSA) levels in circulation of women with cervical carcinoma and to compare our findings with age matched controls. Low levels of SOD and CAT observed in the circulation of cervical cancer patients may be due to their increased utilization to scavenge lipid peroxides as well as sequestration by tumor cells. Higher levels of TSA, AST, ALT and ALP, in the circulation of cervical cancer patients may be used in the diagnosis and treatment monitoring of patients with cervical carcinoma.
宫颈癌是全球第二大常见癌症。抗氧化防御机制效率的降低会加剧自由基诱导的氧化应激程度。已发现循环中必需抗氧化剂水平较低与癌症风险增加有关。我们研究的目的是评估氧化应激程度、超氧化物歧化酶（SOD）、过氧化氢酶（CAT）、铜蓝蛋白等抗氧化剂水平，并评估宫颈癌女性循环中的肿瘤标志物，如天冬氨酸转氨酶（AST）、丙氨酸转氨酶（ALT）、碱性磷酸酶（ALP）和总唾液酸（TSA）水平，并将我们的研究结果与年龄匹配的对照组进行比较。宫颈癌患者循环中观察到的SOD和CAT水平较低，可能是由于它们用于清除脂质过氧化物的利用率增加以及被肿瘤细胞隔离。宫颈癌患者循环中较高水平的TSA、AST、ALT和ALP可用于宫颈癌患者的诊断和治疗监测。
