成人大脑中独特的星形胶质细胞带含有神经干细胞，但缺乏链式迁移。

Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration.

作者信息

Sanai Nader, Tramontin Anthony D, Quiñones-Hinojosa Alfredo, Barbaro Nicholas M, Gupta Nalin, Kunwar Sandeep, Lawton Michael T, McDermott Michael W, Parsa Andrew T, Manuel-García Verdugo José, Berger Mitchel S, Alvarez-Buylla Arturo

机构信息

Department of Neurological Surgery and Brain Tumor Research Center, University of California San Francisco, San Francisco, California 94143, USA.

出版信息

Nature. 2004 Feb 19;427(6976):740-4. doi: 10.1038/nature02301.

DOI:10.1038/nature02301

PMID:14973487

Abstract

The subventricular zone (SVZ) is a principal source of adult neural stem cells in the rodent brain, generating thousands of olfactory bulb neurons every day. If the adult human brain contains a comparable germinal region, this could have considerable implications for future neuroregenerative therapy. Stem cells have been isolated from the human brain, but the identity, organization and function of adult neural stem cells in the human SVZ are unknown. Here we describe a ribbon of SVZ astrocytes lining the lateral ventricles of the adult human brain that proliferate in vivo and behave as multipotent progenitor cells in vitro. This astrocytic ribbon has not been observed in other vertebrates studied. Unexpectedly, we find no evidence of chains of migrating neuroblasts in the SVZ or in the pathway to the olfactory bulb. Our work identifies SVZ astrocytes as neural stem cells in a niche of unique organization in the adult human brain.

摘要

室管膜下区（SVZ）是啮齿动物大脑中成年神经干细胞的主要来源，每天可产生数千个嗅球神经元。如果成年人类大脑中存在类似的生发区域，这可能对未来的神经再生治疗具有重要意义。虽然已经从人类大脑中分离出干细胞，但人类SVZ中成年神经干细胞的身份、组织和功能尚不清楚。在此，我们描述了一条位于成年人类大脑侧脑室壁的SVZ星形胶质细胞带，它们在体内增殖，并在体外表现为多能祖细胞。在其他已研究的脊椎动物中未观察到这种星形胶质细胞带。出乎意料的是，我们在SVZ或通向嗅球的路径中未发现迁移神经母细胞链的证据。我们的研究确定了SVZ星形胶质细胞是成年人类大脑中具有独特组织结构微环境中的神经干细胞。