Rapti Athanasia, Androutsopoulou Theodosia, Andreopoulou Evangelia, Mellou Maria, Leventakos Georgios, Anesti Maria, Mastori Konstantina, Chatzopoulou Myrto, Smyrli Paraskevi, Lakos Nikiforos, Muse Kawthar, Mitsainas Georgios P, Kazanis Ilias
Lab of Developmental Biology, Department of Biology, University of Patras, 26504, Patras, Greece.
Section of Animal Biology, Department of Biology, University of Patras, 26504, Patras, Greece.
Sci Rep. 2025 May 28;15(1):18737. doi: 10.1038/s41598-025-01670-3.
Environmental and behavioral factors have been shown, in experimental settings, to affect neurogenesis in the mouse brain. We found that the density of proliferating neural stem/progenitor cells (NSPCs) and of neuroblasts was significantly lower in the Subependymal Zone stem cell niche of lab mice when compared with mice and pine voles captured in the wild, with seasonal variation observed only in voles. Moreover, levels of proliferation and neurogenesis were found to decrease in proportion to the decrease in the numbers of chromosomes (from the typical 2n = 40 down to 2n = 26) caused by Robertsonian fusions. In contrast, oligodendroglial progenitors and microglial cells were unaffected by wildlife, seasons and chromosomal fusions. When NSPCs were grown in cultures no differences were detected, suggesting that environmental and genetic effects are mediated by non-cell-autonomous mechanisms. These "real-world" data provide a platform for the identification of systemic factors and genetic loci that control postnatal brain neurogenesis.
在实验环境中，环境和行为因素已被证明会影响小鼠大脑中的神经发生。我们发现，与在野外捕获的小鼠和松田鼠相比，实验室小鼠室管膜下区干细胞龛中增殖的神经干细胞/祖细胞（NSPCs）和成神经细胞的密度显著降低，且仅在田鼠中观察到季节性变化。此外，发现增殖和神经发生水平与罗伯逊融合导致的染色体数量减少（从典型的2n = 40降至2n = 26）成比例下降。相比之下，少突胶质祖细胞和小胶质细胞不受野生动物、季节和染色体融合的影响。当NSPCs在培养物中生长时，未检测到差异，这表明环境和遗传效应是由非细胞自主机制介导的。这些“真实世界”的数据为识别控制出生后大脑神经发生的系统因素和基因位点提供了一个平台。
