Evans K C, Peterson A C, Ruiz H E, Costabile R A
Urology Service, Madigan Army Medical Center, Tacoma, Washington 98431, USA.
Int J Impot Res. 2004 Aug;16(4):346-9. doi: 10.1038/sj.ijir.3901160.
Analgesics and topical agents ineffectively inhibit painful erections after penile and urethral surgery. Oral ketoconazole reversibly inhibits testosterone production and has been used empirically at our institution to decrease postoperative erections. We performed a retrospective review of 38 patients who had undergone penile and urethral reconstructive surgery. In all, 31 patients received 400 mg of ketoconazole three times daily for 10-14 days postoperatively (the study group) and seven patients did not receive ketoconazole (the control group). The incidence of postoperative erections, pain, side effects, surgical outcomes and patient satisfaction in each group were compared. Of the control group, 71% reported erections in the immediate postoperative period, and all these patients reported the erections were painful. Only 23% of the patient taking ketoconazole reported postoperative erections, and only 16% reported the erections were painful. We conclude that ketoconazole effectively prevents painful postoperative erections with minimal side effects.
镇痛药和局部用药无法有效抑制阴茎和尿道手术后的疼痛性勃起。口服酮康唑可可逆性抑制睾酮生成，在我们机构已凭经验使用该药来减少术后勃起。我们对38例行阴茎和尿道重建手术的患者进行了一项回顾性研究。总共有31例患者在术后10 - 14天每天3次服用400毫克酮康唑（研究组），7例患者未服用酮康唑（对照组）。比较了每组术后勃起、疼痛、副作用、手术结果及患者满意度的发生率。对照组中，71%的患者报告术后即刻出现勃起，且所有这些患者均称勃起疼痛。服用酮康唑的患者中只有23%报告术后有勃起，只有16%称勃起疼痛。我们得出结论，酮康唑能有效预防术后疼痛性勃起，且副作用最小。
