Stock J A, Kaplan G W
Children's Hospital and Health Center, San Diego, California.
Urology. 1995 Feb;45(2):308-9. doi: 10.1016/0090-4295(95)80022-0.
To determine if ketoconazole, an inhibitor of testosterone synthesis, can prevent postoperative spontaneous erections in patients undergoing penile surgery.
Ketoconazole was administered to 8 patients, aged 14 to 42 years, who underwent penile surgery. All patients received ketoconazole 400 mg orally three times daily starting on the day of surgery. Liver function tests were obtained preoperatively and after the completion of treatment.
Ketoconazole successfully prevented erections in all patients. None of the patients demonstrated liver function abnormalities.
Ketoconazole is a reliable method to prevent postoperative penile erection. With the proper monitoring of liver function tests and the avoidance of drug interactions, ketoconazole therapy also appears to be safe.
确定睾酮合成抑制剂酮康唑能否预防接受阴茎手术患者术后的自发性勃起。
对8例年龄在14至42岁之间接受阴茎手术的患者给予酮康唑治疗。所有患者从手术当天开始每天口服酮康唑400毫克，分三次服用。术前及治疗结束后进行肝功能检查。
酮康唑成功预防了所有患者的勃起。所有患者均未出现肝功能异常。
酮康唑是预防术后阴茎勃起的可靠方法。在适当监测肝功能检查并避免药物相互作用的情况下，酮康唑治疗似乎也是安全的。
