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同期腹腔镜下胃和胆道旁路手术及双侧胸腔镜内脏神经切断术:胰腺癌微创姑息治疗的全套方案

Concomitant laparoscopic gastric and biliary bypass and bilateral thoracoscopic splanchnotomy: the full package of minimally invasive palliation for pancreatic cancer.

作者信息

Ali A S M, Ammori B J

机构信息

Department of Surgery, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK.

出版信息

Surg Endosc. 2003 Dec;17(12):2028-31. doi: 10.1007/s00464-003-4243-8. Epub 2003 Oct 28.

DOI:10.1007/s00464-003-4243-8
PMID:14973750
Abstract

INTRODUCTION

Pancreatic cancer is unresectable in 80% or more of patients. Biliary and duodenal obstruction and intractable abdominal and back pain are the most common complications of the disease. These complications may be palliated effectively using minimally invasive techniques. Their combined application in a single setting is presented and discussed in this article.

CASE REPORT

A 59-year-old man with a locally advanced carcinoma of the head of the pancreas presented with obstructive jaundice and intractable pain requiring opiate analgesia. An attempt at endoscopic biliary stenting was unsuccessful, and a percutaneous biopsy was deemed unsafe. Preoperative magnetic resonance cholangiography showed cystic duct insertion abutting the upper limit of the biliary stricture. A laparoscopic Roux-en-Y hepaticojejunostomy, prophylactic loop gastroenterostomy, and tumor biopsy were combined with a bilateral thoracoscopic splanchnotomy.

RESULT

Surgery and subsequent recovery were uneventful, and the patient was discharged from hospital on the fourth postoperative day off opiates. He remained free of jaundice and severe pain, until 6 months later, when he represented with jaundice, cachexia, and proximal small bowel obstruction secondary to multiple liver and peritoneal metastases. He underwent further palliative laparoscopic enteric bypass with resolution of the intestinal obstruction, but died of the disease 10 days later.

CONCLUSION

Laparoscopic gastric and biliary bypass and bilateral thoracoscopic splanchnotomy may be safely combined to provide an effective comprehensive minimally invasive palliation of incurable pancreatic cancer.

摘要

引言

80%或更多的胰腺癌患者无法进行手术切除。胆管和十二指肠梗阻以及顽固性腹痛和背痛是该疾病最常见的并发症。使用微创技术可以有效缓解这些并发症。本文介绍并讨论了它们在单一情况下的联合应用。

病例报告

一名59岁男性,患有局部晚期胰头癌,出现梗阻性黄疸和顽固性疼痛,需要使用阿片类镇痛药。内镜下胆管支架置入术尝试失败,经皮活检被认为不安全。术前磁共振胆管造影显示胆囊管插入处紧邻胆管狭窄的上限。腹腔镜下Roux-en-Y肝空肠吻合术、预防性袢式胃肠吻合术和肿瘤活检与双侧胸腔镜内脏神经切断术联合进行。

结果

手术及随后的恢复过程顺利,患者术后第四天停用阿片类药物出院。他一直没有黄疸和严重疼痛,直到6个月后,再次出现黄疸、恶病质以及继发于多处肝脏和腹膜转移的近端小肠梗阻。他接受了进一步的姑息性腹腔镜肠旁路手术,肠梗阻得到缓解,但10天后死于该疾病。

结论

腹腔镜胃和胆管旁路手术以及双侧胸腔镜内脏神经切断术可以安全地联合应用,为无法治愈的胰腺癌提供有效的综合微创姑息治疗。

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本文引用的文献

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Surg Endosc. 2002 Feb;16(2):310-2. doi: 10.1007/s00464-001-9061-2. Epub 2001 Nov 12.
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Fluoroscopically guided placement of a covered self-expandable metallic stent for malignant antroduodenal obstructions: preliminary results in 18 patients.荧光透视引导下置入覆膜自膨式金属支架治疗恶性十二指肠梗阻:18例初步结果
AJR Am J Roentgenol. 2002 Apr;178(4):847-52. doi: 10.2214/ajr.178.4.1780847.
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Expandable metal stents for the palliation of malignant gastroduodenal obstruction.
用于缓解恶性胃十二指肠梗阻的可扩张金属支架
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Endoscopic palliation of malignant gastric outlet obstruction using self-expanding metal stents: experience in 36 patients.使用自膨式金属支架对恶性胃出口梗阻进行内镜下姑息治疗:36例患者的经验
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Randomized trial of gastrojejunostomy with duodenal partition versus antrectomy in unresectable periampullary cancer.十二指肠分隔胃空肠吻合术与胃窦切除术治疗不可切除壶腹周围癌的随机试验
Zhonghua Yi Xue Za Zhi (Taipei). 2001 Aug;64(8):443-50.
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Thoracoscopic splanchnicectomy for pain control in patients with unresectable carcinoma of the pancreas.胸腔镜内脏神经切除术用于无法切除的胰腺癌患者的疼痛控制
Surg Endosc. 2000 Aug;14(8):717-20. doi: 10.1007/s004640000185.
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Arch Surg. 2000 Mar;135(3):332-5. doi: 10.1001/archsurg.135.3.332.
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Is prophylactic gastrojejunostomy indicated for unresectable periampullary cancer? A prospective randomized trial.预防性胃空肠吻合术适用于无法切除的壶腹周围癌吗?一项前瞻性随机试验。
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World J Surg. 1999 Jul;23(7):688-92. doi: 10.1007/pl00012369.
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