Ali A S M, Ammori B J
Department of Surgery, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK.
Surg Endosc. 2003 Dec;17(12):2028-31. doi: 10.1007/s00464-003-4243-8. Epub 2003 Oct 28.
Pancreatic cancer is unresectable in 80% or more of patients. Biliary and duodenal obstruction and intractable abdominal and back pain are the most common complications of the disease. These complications may be palliated effectively using minimally invasive techniques. Their combined application in a single setting is presented and discussed in this article.
A 59-year-old man with a locally advanced carcinoma of the head of the pancreas presented with obstructive jaundice and intractable pain requiring opiate analgesia. An attempt at endoscopic biliary stenting was unsuccessful, and a percutaneous biopsy was deemed unsafe. Preoperative magnetic resonance cholangiography showed cystic duct insertion abutting the upper limit of the biliary stricture. A laparoscopic Roux-en-Y hepaticojejunostomy, prophylactic loop gastroenterostomy, and tumor biopsy were combined with a bilateral thoracoscopic splanchnotomy.
Surgery and subsequent recovery were uneventful, and the patient was discharged from hospital on the fourth postoperative day off opiates. He remained free of jaundice and severe pain, until 6 months later, when he represented with jaundice, cachexia, and proximal small bowel obstruction secondary to multiple liver and peritoneal metastases. He underwent further palliative laparoscopic enteric bypass with resolution of the intestinal obstruction, but died of the disease 10 days later.
Laparoscopic gastric and biliary bypass and bilateral thoracoscopic splanchnotomy may be safely combined to provide an effective comprehensive minimally invasive palliation of incurable pancreatic cancer.
80%或更多的胰腺癌患者无法进行手术切除。胆管和十二指肠梗阻以及顽固性腹痛和背痛是该疾病最常见的并发症。使用微创技术可以有效缓解这些并发症。本文介绍并讨论了它们在单一情况下的联合应用。
一名59岁男性,患有局部晚期胰头癌,出现梗阻性黄疸和顽固性疼痛,需要使用阿片类镇痛药。内镜下胆管支架置入术尝试失败,经皮活检被认为不安全。术前磁共振胆管造影显示胆囊管插入处紧邻胆管狭窄的上限。腹腔镜下Roux-en-Y肝空肠吻合术、预防性袢式胃肠吻合术和肿瘤活检与双侧胸腔镜内脏神经切断术联合进行。
手术及随后的恢复过程顺利,患者术后第四天停用阿片类药物出院。他一直没有黄疸和严重疼痛,直到6个月后,再次出现黄疸、恶病质以及继发于多处肝脏和腹膜转移的近端小肠梗阻。他接受了进一步的姑息性腹腔镜肠旁路手术,肠梗阻得到缓解,但10天后死于该疾病。
腹腔镜胃和胆管旁路手术以及双侧胸腔镜内脏神经切断术可以安全地联合应用,为无法治愈的胰腺癌提供有效的综合微创姑息治疗。