Verhagen A P, Scholten-Peeters G G M, de Bie R A, Bierma-Zeinstra S M A
Dept. of General Practice, Erasmus Medical Centre, University of Rotterdam, PO Box 1738, 3000 DR Rotterdam, NETHERLANDS.
Cochrane Database Syst Rev. 2004(1):CD003338. doi: 10.1002/14651858.CD003338.pub2.
Our previous review examining conservative treatments for whiplash was published in 2001. Since then, new trials have been published.Whiplash-associated disorders (WAD) can be classified by the severity of signs and symptoms: WAD Grade 0 indicates no complaints or physical signs; Grade 1 indicates neck complaints but no physical signs; Grade 2 indicates neck complaints and musculoskeletal signs; Grades 3 and 4 indicate neck complaints and neurological signs or fracture/dislocation, respectively.
To assess the effectiveness of conservative treatment in patients with WAD Grades 1 or 2.
We completed a computerised search of CENTRAL, MEDLINE, EMBASE, CINAHL, PsycLIT, and PEDro, to April 2003. We also screened references of identified trials and relevant systematic reviews.
Studies were selected if they were a (randomised) clinical trial, examined patients with a WAD, examined conservative treatments, measured one of: pain, global perceived effect or participation in daily activities, and were published in English, French, German or Dutch.
Two reviewers independently assessed the methodological quality using the Delphi list and extracted the data using standardised forms. Because the population, interventions and outcome measures were heterogeneous, we used a rating system with levels of evidence rather than statistical pooling for the analysis. Clinically relevant improvement was defined as a 15% improvement relative to a control. A pre-planned stratified analysis was performed in three groups.
We found four new studies since the previous review, resulting in 15 studies that met the inclusion criteria. Just one study evaluated patients with chronic WAD. Only three studies satisfied one of our criteria of high quality, indicating overall a poor methodological quality. The broad array of conservative interventions were divided into passive and active interventions and were compared with each other, no treatment, or a placebo group. There was limited evidence that both passive and active interventions seemed to be more effective than no treatment. Contrary to our earlier review, we found conflicting evidence about the effectiveness of active interventions compared to passive ones. All but one study mentioned positive results, but the actual data of the high quality studies were conflicting.
REVIEWER'S CONCLUSIONS: When looking at the actual data presented in the current included trials, our conclusion from the previous version of this review, that 'rest makes rusty', can no longer be justified. There is a trend suggesting that active interventions are more effective than passive ones, but no clear conclusion can be drawn. We can draw no conclusion about the most effective therapy for patients with chronic WAD, because only one low quality trial was found.
我们之前关于鞭打损伤保守治疗的综述发表于2001年。自那时起,已有新的试验发表。鞭打相关疾病(WAD)可根据体征和症状的严重程度进行分类:WAD 0级表示无主诉或体征;1级表示颈部主诉但无体征;2级表示颈部主诉和肌肉骨骼体征;3级和4级分别表示颈部主诉和神经体征或骨折/脱位。
评估保守治疗对1级或2级WAD患者的有效性。
我们对截至2003年4月的Cochrane系统评价数据库、医学期刊数据库、荷兰医学文摘数据库、护理学与健康领域数据库、心理学文摘数据库和循证医学数据库进行了计算机检索。我们还筛选了已识别试验的参考文献和相关的系统评价。
入选的研究需为(随机)临床试验,研究WAD患者,研究保守治疗方法,测量疼痛、整体感觉效果或日常活动参与度中的一项,且以英文、法文、德文或荷兰文发表。
两名评价员使用德尔菲清单独立评估方法学质量,并使用标准化表格提取数据。由于研究对象、干预措施和结局指标存在异质性,我们使用证据等级评分系统而非统计合并进行分析。临床相关改善定义为相对于对照组改善15%。进行了一项预先计划的三组分层分析。
自上次综述以来,我们发现了四项新研究,共有15项研究符合纳入标准。仅有一项研究评估了慢性WAD患者。只有三项研究符合我们的高质量标准之一,总体方法学质量较差。广泛的保守干预措施分为被动干预和主动干预,并相互比较,或与不治疗组或安慰剂组比较。有有限的证据表明,被动和主动干预似乎都比不治疗更有效。与我们早期的综述相反,我们发现主动干预与被动干预相比有效性的证据相互矛盾。除一项研究外,所有研究均提及了阳性结果,但高质量研究的实际数据相互矛盾。
从当前纳入试验所呈现的实际数据来看,我们在上一版综述中得出的“休息会生锈”这一结论已不再合理。有趋势表明主动干预比被动干预更有效,但无法得出明确结论。对于慢性WAD患者的最有效治疗方法,我们无法得出结论,因为仅发现一项低质量试验。