Vass Géza, Huszár Eva, Barát Erzsébet, Horváth Ildikó
Országos Korányi Tbc és Pulmonológiai Intézet, Kórélettani Osztály, Budapest.
Orv Hetil. 2003 Dec 21;144(51):2517-24.
In the middle of the nineties a new, non-invasive method for investigation of the lung aroused the interest of many researchers: the exhaled breath condensate. It shows the extent of the interest that in the last five years more than 80 original articles have been published in this theme. Many substances are found in the expired breath which are detectable in the liquid that we obtain by cooling (= condensing) the exhaled breath. The advantages of this method are that it is non-invasive, convenient, it could be performed with mechanically ventilated patients as well as with children. The most studied substance is the hydrogen-peroxide, which is the marker of oxidative stress, and its level in condensate is elevated in numerous inflammatory diseases. 8-isoprostane was also studied a lot, which is another marker of oxidative stress. Numerous substances could be even measured in condensate, so the decay-product of nitric-oxide (nitrite, nitrate, nitrotyrosine), further nitrosothiol, adenosine, ammonia, different ions, leukotrienes, cytokines; recently even other feature of condensate is examined, such as its pH. The different mediators could help us to know better the diseases, support the diagnosis, follow the treatment or the disease. In this study the authors attempt to present the most important knowledge till now.
九十年代中期，一种用于肺部检查的新型非侵入性方法引起了众多研究人员的兴趣：呼出气冷凝物。这显示出了极大的关注度，在过去五年里，围绕该主题已发表了80多篇原创文章。在呼出气中发现了许多物质，这些物质在我们通过冷却（即冷凝）呼出气所得到的液体中能够被检测到。该方法的优点是无创、便捷，机械通气患者和儿童均可进行。研究最多的物质是过氧化氢，它是氧化应激的标志物，在众多炎症性疾病中其在冷凝物中的水平会升高。8-异前列腺素也被大量研究，它是氧化应激的另一种标志物。甚至可以在冷凝物中测量多种物质，如一氧化氮的分解产物（亚硝酸盐、硝酸盐、硝基酪氨酸）、其他亚硝基硫醇、腺苷、氨、不同离子、白三烯、细胞因子；最近甚至还对冷凝物的其他特性进行了研究，比如其pH值。这些不同的介质有助于我们更好地了解疾病，辅助诊断，跟踪治疗或病情。在本研究中，作者试图呈现目前最重要的知识。
