Fujikane T, Fujiuchi S, Yamazaki Y, Matsumoto H, Takahashi M, Fujita Y, Shimizu T, Kikuchi K
Department of Clinical Research, National Dohoku Hospital, Asahikawa, Japan.
Int J Tuberc Lung Dis. 2004 Jan;8(1):39-44.
The incidence of tuberculosis in Japan has fallen rapidly in the past 50 years, to 27.9 cases per 100,000 population in 2001.
To assess the molecular epidemiology of tuberculosis in the north Hokkaido district, Japan.
Restriction fragment length polymorphism analysis was consecutively performed on Mycobacterium tuberculosis strains from patients with pulmonary tuberculosis from April 1999 to March 2002.
Of 229 patients, strains from 227 (99.1%) were available for analysis. The mean age of the patients analysed was 69.4 years. There was one immigrant patient. Two hundred and seven patients had six or more copies of IS6110. Of these, 16 (7.7%) in eight clusters had identical patterns, 120 (58.0%) belonged to five groups that had similar patterns (Dice coefficient >0.7) and 80 (38.6%) belonged to the 35 groups with the most common patterns (Dice coefficient >0.9).
These results may reflect the epidemiological characteristics, age and migration of the residents and the incidence of tuberculosis of the area, and also those of Japan: many elderly patients were infected in the past, when the incidence of tuberculosis was very high.
在过去50年中，日本的结核病发病率迅速下降，2001年降至每10万人口27.9例。
评估日本北海道地区结核病的分子流行病学。
对1999年4月至2002年3月期间肺结核患者的结核分枝杆菌菌株连续进行限制性片段长度多态性分析。
229例患者中，227例（99.1%）的菌株可供分析。分析患者的平均年龄为69.4岁。有1例移民患者。207例患者有6个或更多拷贝的IS6110。其中，8个簇中的16例（7.7%）具有相同的图谱，120例（58.0%）属于5个具有相似图谱的组（Dice系数>0.7），80例（38.6%）属于35个具有最常见图谱的组（Dice系数>0.9）。
这些结果可能反映了该地区居民的流行病学特征、年龄和迁移情况以及结核病发病率，也反映了日本的情况：过去结核病发病率很高时，许多老年患者受到了感染。
