四维中的策略与模型构建：作为高斯平稳随机过程的基因型x年龄相互作用的零模型
Strategy and model building in the fourth dimension: a null model for genotype x age interaction as a Gaussian stationary stochastic process.
作者信息
Diego Vincent P, Almasy Laura, Dyer Thomas D, Soler Júlia M P, Blangero John
机构信息
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas, USA.
出版信息
BMC Genet. 2003 Dec 31;4 Suppl 1(Suppl 1):S34. doi: 10.1186/1471-2156-4-S1-S34.
BACKGROUND
Using univariate and multivariate variance components linkage analysis methods, we studied possible genotype x age interaction in cardiovascular phenotypes related to the aging process from the Framingham Heart Study.
RESULTS
We found evidence for genotype x age interaction for fasting glucose and systolic blood pressure.
CONCLUSIONS
There is polygenic genotype x age interaction for fasting glucose and systolic blood pressure and quantitative trait locus x age interaction for a linkage signal for systolic blood pressure phenotypes located on chromosome 17 at 67 cM.
背景
我们使用单变量和多变量方差成分连锁分析方法，对弗雷明汉心脏研究中与衰老过程相关的心血管表型中可能存在的基因型×年龄相互作用进行了研究。
结果
我们发现了空腹血糖和收缩压存在基因型×年龄相互作用的证据。
结论
空腹血糖和收缩压存在多基因基因型×年龄相互作用，位于17号染色体67厘摩处的收缩压表型连锁信号存在数量性状基因座×年龄相互作用。
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