Lange K
Am J Med Genet. 1986 Jul;24(3):483-91. doi: 10.1002/ajmg.1320240311.
Temporal variation in traits has long been a central theme in epidemiology. However, human geneticists have largely avoided this topic. Recently, several authors have shown how temporal variation in relative-to-relative covariances can be accommodated within the framework of variance components analysis. The present paper attempts to clarify the mathematics implicit in their approach. A stochastic mechanism is discussed that causes covariances to converge or diverge exponentially fast as relatives cohabit or lead separate lives.
性状的时间变化长期以来一直是流行病学的核心主题。然而,人类遗传学家在很大程度上回避了这个话题。最近,几位作者展示了如何在方差成分分析的框架内处理相对 - 相对协方差的时间变化。本文试图阐明他们方法中隐含的数学原理。我们讨论了一种随机机制,该机制会导致协方差随着亲属共同居住或分开生活而以指数速度快速收敛或发散。