在弗雷明汉心脏研究中，性别与体重指数（BMI）的相互作用揭示了高血压存在连锁关系的证据。
Interaction of gender and body mass index (BMI) reveals evidence of linkage for hypertension in the Framingham Heart Study.
作者信息
Daley Denise, Edwards Shannon R, Song Yeunjoo, Baechle Dan, Puppala Sobha, Schick J H, Olson Jane M, Goddard Katrina A B
机构信息
Department of Epidemiology and Biostatistics, Rammelkamp Center for Education and Research, MetroHealth Campus, Case Western Reserve University, Cleveland, Ohio, USA.
出版信息
BMC Genet. 2003 Dec 31;4 Suppl 1(Suppl 1):S45. doi: 10.1186/1471-2156-4-S1-S45.
BACKGROUND
Genetic heterogeneity and complex biologic mechanisms of blood pressure regulation pose significant challenges to the identification of susceptibility loci influencing hypertension. Previous linkage studies have reported regions of interest, but lack consistency across studies. Incorporation of covariates, in particular the interaction between two independent risk factors (gender and BMI) greatly improved our ability to detect linkage.
RESULTS
We report a highly significant signal for linkage to chromosome 2p, a region that has been implicated in previous linkage studies, along with several suggestive linkage regions.
CONCLUSION
We demonstrate the importance of including covariates in the linkage analysis when the phenotype is complex.
背景
血压调节的遗传异质性和复杂生物学机制给识别影响高血压的易感基因座带来了重大挑战。以往的连锁研究报告了一些感兴趣的区域，但各研究之间缺乏一致性。纳入协变量，特别是两个独立风险因素（性别和体重指数）之间的相互作用，极大地提高了我们检测连锁的能力。
结果
我们报告了与2号染色体p臂连锁的一个高度显著信号，该区域在以往的连锁研究中已有涉及，同时还有几个提示性的连锁区域。
结论
我们证明了在表型复杂时，在连锁分析中纳入协变量的重要性。
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