Zabaneh Delilah, Mackay Ian J
Oxagen Limited, 91 Milton Park, Abingdon, Oxon, United Kingdom.
BMC Genet. 2003 Dec 31;4 Suppl 1(Suppl 1):S61. doi: 10.1186/1471-2156-4-S1-S61.
A genome-wide linkage scan was performed on Replicate 1 of the simulated data for fasting triglyceride levels. The aim of this study was to implement mixed-model methodology to estimate breeding values for each individual for this trait and to assess the merit of these breeding values in linkage analysis. These breeding values utilize all the pedigree information, and the genetic and phenotypic correlations with other measured traits across the two cohorts. A genome-wide linkage scan was run on both the new breeding value traits and the original traits.
Using breeding values, a maximum LOD of 7.78 was found on chromosome 5 at a position very close to a gene underlying the triglyceride levels. This effect was not detected using the original trait.
The results imply that estimating breeding values may be a suitable method of deriving traits for use in genome-wide scans.
对模拟数据的复制品1进行了空腹甘油三酯水平的全基因组连锁扫描。本研究的目的是采用混合模型方法估计该性状每个个体的育种值，并评估这些育种值在连锁分析中的价值。这些育种值利用了所有的系谱信息，以及两个队列中与其他测量性状的遗传和表型相关性。对新的育种值性状和原始性状都进行了全基因组连锁扫描。
利用育种值，在5号染色体上一个非常接近甘油三酯水平相关基因的位置发现了最大LOD值为7.78。使用原始性状未检测到这种效应。
结果表明，估计育种值可能是一种适用于全基因组扫描的性状推导方法。
