全基因组范围内对大量饮酒的筛查。
Genome-wide screen for heavy alcohol consumption.
作者信息
Wyszynski Diego F, Panhuysen Carolien I, Ma Qianli, Yip Agustin G, Wilcox Marsha, Erlich Porat, Farrer Lindsay A
机构信息
Genetics Program, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA.
出版信息
BMC Genet. 2003 Dec 31;4 Suppl 1(Suppl 1):S106. doi: 10.1186/1471-2156-4-S1-S106.
Abstract
BACKGROUND
To find specific genes predisposing to heavy alcohol consumption (self-reported consumption of 24 grams or more of alcohol per day among men and 12 grams or more among women), we studied 330 families collected by the Framingham Heart Study made available to participants in the Genetic Analysis Workshop 13 (GAW13).
RESULTS
Parametric and nonparametric methods of linkage analysis were used. No significant evidence of linkage was found; however, weak signals were identified in several chromosomal regions, including 1p22, 4q12, 4q25, and 11q24, which are in the vicinity of those reported in other similar studies.
CONCLUSION
Our study did not reveal significant evidence of linkage to heavy alcohol use; however, we found weak confirmation of studies carried out in other populations.
摘要
背景
为了找到导致大量饮酒（男性自我报告每天饮酒24克或更多，女性每天饮酒12克或更多）的特定基因，我们研究了弗雷明汉心脏研究收集的330个家庭，这些家庭数据在遗传分析研讨会13（GAW13）中提供给了参与者。
结果
采用了参数和非参数连锁分析方法。未发现显著的连锁证据；然而，在几个染色体区域发现了微弱信号，包括1p22、4q12、4q25和11q24，这些区域与其他类似研究报告的区域相邻。
结论
我们的研究未揭示与大量饮酒相关的显著连锁证据；然而，我们发现了对其他人群研究的微弱证实。
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