Bergen Andrew W, Yang Xiaohong Rose, Bai Yan, Beerman Michael B, Goldstein Alisa M, Goldin Lynn R
Core Genotyping Facility, Advanced Technology Center, National Cancer Institute, NIH, DHHS, Gaithersburg, Maryland, USA.
BMC Genet. 2003 Dec 31;4 Suppl 1(Suppl 1):S101. doi: 10.1186/1471-2156-4-S1-S101.
Pedigree, demographic, square-root transformed maximum alcohol (SRMAXAPD) and maximum cigarette (MAXCPD) consumption, and genome-wide scan data from the Framingham Heart Study (FHS) were used to investigate genetic factors that may affect alcohol and cigarette consumption in this population-based sample.
A significant sister:sister correlation greater than spouse correlation was observed for MAXCPD only. Single-point sib-pair regression analysis provided nominal evidence for linkage of loci to both SRMAXAPD and MAXCPD consumption traits, with more significant evidence of linkage to SRMAXAPD than to MAXCPD. One genomic region, chr9q21.11, exhibits significant multi-point sib-pair regression to SRMAXAPD.
SRMAXAPD exhibits greater evidence for genetic linkage than does MAXCPD in the FHS sample. Four regions of the genome exhibiting nominal evidence for linkage to SRMAXAPD in the FHS sample correspond to regions of the genome previously identified as linked to alcoholism or related traits in the family data set ascertained on individuals affected with alcohol dependence known as COGA.
利用来自弗雷明汉心脏研究（FHS）的家系、人口统计学数据、平方根转换后的最大酒精摄入量（SRMAXAPD）和最大香烟摄入量（MAXCPD），以及全基因组扫描数据，来研究在这个基于人群的样本中可能影响酒精和香烟消费的遗传因素。
仅在MAXCPD方面观察到姐妹间的显著相关性大于配偶间的相关性。单点同胞对回归分析为基因座与SRMAXAPD和MAXCPD消费性状的连锁提供了名义证据，其中与SRMAXAPD连锁的证据比与MAXCPD连锁的证据更显著。一个基因组区域，即9号染色体q21.11，对SRMAXAPD表现出显著的多点同胞对回归。
在FHS样本中，SRMAXAPD比MAXCPD表现出更强的遗传连锁证据。在FHS样本中，有四个基因组区域显示出与SRMAXAPD连锁的名义证据，这些区域与先前在基于酒精依赖患者确定的家族数据集中被确定为与酒精中毒或相关性状连锁的基因组区域相对应，该家族数据集称为COGA。
