Wilson C A, Berkowitz B A, Sato Y, Ando N, Handa J T, de Juan E
Department of Ophthalmology, Duke University Medical Center, Durham, NC 27710.
Arch Ophthalmol. 1992 Aug;110(8):1155-9. doi: 10.1001/archopht.1992.01080200135041.
The effect of corticosteroid treatment on blood-retinal barrier breakdown caused by argon-laser panretinal photocoagulation was evaluated in the rabbit eye. One day before photocoagulation, eyes were given either a sub-Tenon (20-mg) or intravitreal (2-mg) injection of triamcinolone acetonide. The severity of blood-retinal barrier breakdown was measured after photocoagulation using rapid sequential magnetic resonance imaging following intravenous administration of gadolinium diethylenetriaminepentaacetic acid. Leakage of gadolinium diethylenetriaminepentaacetic acid into the vitreous space was significantly lower in eyes that received intravitreal triamcinolone acetonide than in control eyes (P = .007); however, sub-Tenon triamcinolone acetonide produced no significant reduction in leakage (P = .65) compared with controls. Fluorescein angiography supported the magnetic resonance imaging findings. We conclude that retinal photocoagulation in the rabbit eye produces blood-retinal barrier breakdown that is partially amenable to corticosteroid treatment.
在兔眼中评估了皮质类固醇治疗对氩激光全视网膜光凝所致血视网膜屏障破坏的影响。光凝前一天，给兔眼行球周（20mg）或玻璃体内（2mg）注射曲安奈德。在静脉注射钆喷酸葡胺后，采用快速序列磁共振成像测量光凝后血视网膜屏障破坏的严重程度。接受玻璃体内曲安奈德注射的兔眼，钆喷酸葡胺向玻璃体腔的渗漏明显低于对照眼（P = 0.007）；然而，与对照相比，球周注射曲安奈德并未使渗漏显著减少（P = 0.65）。荧光素血管造影支持磁共振成像的结果。我们得出结论，兔眼视网膜光凝会导致血视网膜屏障破坏，部分可通过皮质类固醇治疗改善。
