Okada Fumito, Ando Yumiko, Kondo Yoshiyuki, Matsumoto Shunro, Maeda Toru, Mori Hiromu
Department of Radiology, Oita Medical University, Idaigaoka 1-1, Hasama-machi, Oita 879-5593, Japan.
AJR Am J Roentgenol. 2004 Mar;182(3):761-7. doi: 10.2214/ajr.182.3.1820761.
The aim of this study was to assess pulmonary CT findings in patients with adult T-cell leukemia or lymphoma.
We retrospectively reviewed CT scans of the lung in 87 patients with adult T-cell leukemia or lymphoma who had undergone chest CT between January 1996 and March 2002 at two institutions. The CT scans were interpreted by two chest radiologists working in consensus. Parenchymal abnormalities (ground-glass attenuation, consolidation, nodules, thickening of bronchovascular bundles, interlobular septal thickening, honeycombing, crazy-paving appearance, and bronchiectasis) were evaluated, as were enlarged lymph nodes, pleural effusion, and pleural thickening. In 46 patients who underwent surgical biopsy or autopsy, CT-pathologic correlation was performed with the actual specimens by a pathologist and two chest radiologists.
On the CT scans, abnormal findings were seen in 60 patients (69.0%). CT findings consisted of ground-glass attenuation (n = 37), centrilobular nodules (n = 25), thickening of bronchovascular bundles (n = 22), and consolidation (n = 13). These abnormalities were predominantly seen in the peripheral lung parenchyma (n = 26). Pathologically, these findings corresponded with atypical lymphocyte infiltration along the interstitium and the alveolar spaces. Pleural effusion and enlarged lymph nodes were found in 22 and 27 patients, respectively.
CT findings in patients with adult T-cell leukemia or lymphoma consisted mainly of ground-glass attenuation, centrilobular nodules, and thickening of the bronchovascular bundles in the peripheral lung. These findings, although nonspecific, are considered suggestive of thoracic involvement in patients with adult T-cell leukemia or lymphoma.
本研究旨在评估成人T细胞白血病或淋巴瘤患者的肺部CT表现。
我们回顾性分析了1996年1月至2002年3月期间在两家机构接受胸部CT检查的87例成人T细胞白血病或淋巴瘤患者的肺部CT扫描图像。CT扫描图像由两位胸部放射科医生共同解读。评估了实质异常（磨玻璃影、实变、结节、支气管血管束增厚、小叶间隔增厚、蜂窝状改变、铺路石样表现及支气管扩张）以及肿大淋巴结、胸腔积液和胸膜增厚情况。对46例行手术活检或尸检的患者，由一名病理学家和两位胸部放射科医生将CT表现与实际标本进行对照分析。
在CT扫描中，60例患者（69.0%）有异常表现。CT表现包括磨玻璃影（n = 37）、小叶中心结节（n = 25）、支气管血管束增厚（n = 22）及实变（n = 13）。这些异常主要见于肺外周实质（n = 26）。病理上，这些表现与沿间质和肺泡腔的非典型淋巴细胞浸润相符。分别有22例和27例患者发现胸腔积液和肿大淋巴结。
成人T细胞白血病或淋巴瘤患者的CT表现主要为磨玻璃影、小叶中心结节及肺外周支气管血管束增厚。这些表现虽不具特异性，但被认为提示成人T细胞白血病或淋巴瘤患者存在胸部受累。
