Rinaldi Ross, Maruccio Giuseppe, Biasco Adriana, Visconti Paolo, Arima Valentina, Cingolani Roberto
National Nanotechnology Laboratory of INFM, Dipartimento di Ingegneria dell'Innovazione, University of Lecce, Lecce, Italy.
Ann N Y Acad Sci. 2003 Dec;1006:187-97. doi: 10.1196/annals.1292.012.
Because of their natural functional characteristics, involving inter- and intramolecular electron transfer, metalloproteins are good candidates for biomolecular nanoelectronics. In particular, blue copper proteins, such as azurin, can bind gold via a disulfide site present on its surface and they have a natural electron transfer activity that can be exploited for the realization of molecular switches whose conduction state can be controlled by tuning their redox state through an external voltage source. We report on the implementation of a prototype of protein transistor operating in air and in the solid state, based on this class of proteins. The three terminal devices exhibit various functions depending on the relative source-drain and gate-drain voltages bias, opening a way to the implementation of a new generation of logic architectures.
由于其涉及分子间和分子内电子转移的天然功能特性，金属蛋白是生物分子纳米电子学的理想候选者。特别是，蓝色铜蛋白，如天青蛋白，可以通过其表面存在的二硫键位点与金结合，并且它们具有天然的电子转移活性，可用于实现分子开关，其传导状态可以通过外部电压源调节其氧化还原状态来控制。我们报道了基于这类蛋白质的在空气中和固态下工作的蛋白质晶体管原型的实现。三端器件根据相对源漏和栅漏电压偏置表现出各种功能，为新一代逻辑架构的实现开辟了道路。
