Institute for Bioengineering of Catalonia (IBEC), Baldiri Reixac 15-21, Barcelona 08028 Spain.
Nano Lett. 2012 Jun 13;12(6):2679-84. doi: 10.1021/nl2028969. Epub 2011 Oct 10.
Single protein junctions consisting of azurin bridged between a gold substrate and the probe of an electrochemical tunneling microscope (ECSTM) have been obtained by two independent methods that allowed statistical analysis over a large number of measured junctions. Conductance measurements yield (7.3 ± 1.5) × 10(-6)G(0) in agreement with reported estimates using other techniques. Redox gating of the protein with an on/off ratio of 20 was demonstrated and constitutes a proof-of-principle of a single redox protein field-effect transistor.
通过两种独立的方法获得了由金基底和电化学隧道显微镜（ECSTM）探针之间桥连的天青蛋白组成的单个蛋白质结，这两种方法允许对大量测量结进行统计分析。电导测量得出（7.3 ± 1.5）×10-6G0，与使用其他技术报告的估计值一致。该蛋白质的氧化还原门控具有 20 的开/关比，这构成了单个氧化还原蛋白质场效应晶体管的原理证明。
