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Biomedicine. Will the real cholesterol transporter please stand up.

作者信息

Klett Eric L, Patel Shailesh B

机构信息

Division of Endocrinology, Diabetes and Medical Genetics, Medical University of South Carolina, Charleston, SC 29403, USA.

出版信息

Science. 2004 Feb 20;303(5661):1149-50. doi: 10.1126/science.1095519.

DOI:10.1126/science.1095519
PMID:14976303
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1237009/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e36/1237009/9f43027f362d/nihms4349f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e36/1237009/9f43027f362d/nihms4349f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e36/1237009/9f43027f362d/nihms4349f1.jpg

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4
Inhibition of cholesterol absorption by SCH 58053 in the mouse is not mediated via changes in the expression of mRNA for ABCA1, ABCG5, or ABCG8 in the enterocyte.SCH 58053对小鼠胆固醇吸收的抑制作用并非通过肠细胞中ABCA1、ABCG5或ABCG8的mRNA表达变化介导。
J Lipid Res. 2002 Nov;43(11):1864-74. doi: 10.1194/jlr.m200144-jlr200.
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本文引用的文献

1
Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption.尼曼-匹克C1样1蛋白对肠道胆固醇吸收至关重要。
Science. 2004 Feb 20;303(5661):1201-4. doi: 10.1126/science.1093131.
2
Microsomal triglyceride transfer protein: a protein complex required for the assembly of lipoprotein particles.微粒体甘油三酯转运蛋白：一种脂蛋白颗粒组装所需的蛋白质复合物。
Trends Cell Biol. 1995 Aug;5(8):317-21. doi: 10.1016/s0962-8924(00)89054-6.
3
Lipid rafts in epithelial brush borders: atypical membrane microdomains with specialized functions.
一种新型的哺乳动物跨膜蛋白家族，参与胆固醇运输。
Sci Rep. 2017 Aug 7;7(1):7450. doi: 10.1038/s41598-017-07077-z.
4
Plant sterol enriched functional food and atherosclerosis.富含植物甾醇的功能性食品与动脉粥样硬化
Br J Pharmacol. 2017 Jun;174(11):1281-1289. doi: 10.1111/bph.13764. Epub 2017 Apr 5.
5
Efficacy of ezetimibe is not related to NPC1L1 gene polymorphisms in a pilot study of Chilean hypercholesterolemic subjects.在一项针对智利高胆固醇血症患者的初步研究中，依泽替米贝的疗效与NPC1L1基因多态性无关。
Mol Diagn Ther. 2015 Feb;19(1):45-52. doi: 10.1007/s40291-014-0128-x.
6
Visualization of lipid metabolism in the zebrafish intestine reveals a relationship between NPC1L1-mediated cholesterol uptake and dietary fatty acid.斑马鱼肠道脂质代谢的可视化揭示了NPC1L1介导的胆固醇摄取与膳食脂肪酸之间的关系。
Chem Biol. 2012 Jul 27;19(7):913-25. doi: 10.1016/j.chembiol.2012.05.018. Epub 2012 Jun 28.
7
Zebrafish lipid metabolism: from mediating early patterning to the metabolism of dietary fat and cholesterol.斑马鱼的脂质代谢：从介导早期模式形成到膳食脂肪和胆固醇的代谢
Methods Cell Biol. 2011;101:111-41. doi: 10.1016/B978-0-12-387036-0.00005-0.
8
Balancing cholesterol synthesis and absorption in the gastrointestinal tract.平衡胃肠道中的胆固醇合成和吸收。
J Clin Lipidol. 2008 Apr;2(2):S1-3. doi: 10.1016/j.jacl.2008.01.004.
9
Hepatic Niemann-Pick C1-like 1 regulates biliary cholesterol concentration and is a target of ezetimibe.肝脏尼曼-匹克C1样蛋白1调节胆汁胆固醇浓度，是依泽替米贝的作用靶点。
J Clin Invest. 2007 Jul;117(7):1968-78. doi: 10.1172/JCI30060.
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Sterolins ABCG5 and ABCG8: regulators of whole body dietary sterols.固醇转运蛋白ABCG5和ABCG8：全身膳食固醇的调节因子。
Pflugers Arch. 2007 Feb;453(5):745-52. doi: 10.1007/s00424-005-0040-7. Epub 2006 Jan 27.
上皮刷状缘中的脂筏：具有特殊功能的非典型膜微区
Biochim Biophys Acta. 2003 Oct 31;1617(1-2):1-9. doi: 10.1016/j.bbamem.2003.09.005.
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Genetic defenses against noncholesterol sterols.针对非胆固醇固醇的遗传防御机制。
Curr Opin Lipidol. 2003 Aug;14(4):341-5. doi: 10.1097/01.mol.0000083763.66245.18.
5
Mutations in a Sar1 GTPase of COPII vesicles are associated with lipid absorption disorders.COPII囊泡的Sar1 GTP酶突变与脂质吸收障碍有关。
Nat Genet. 2003 May;34(1):29-31. doi: 10.1038/ng1145.
6
Roles of acyl-coenzyme A:cholesterol acyltransferase-1 and -2.酰基辅酶A：胆固醇酰基转移酶-1和-2的作用。
Curr Opin Lipidol. 2001 Jun;12(3):289-96. doi: 10.1097/00041433-200106000-00008.
7
Traffic COPs of the early secretory pathway.早期分泌途径的交通警察
Traffic. 2000 May;1(5):371-7. doi: 10.1034/j.1600-0854.2000.010501.x.
8
Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption.鉴定出一个在膳食胆固醇吸收调节中起重要作用的基因ABCG5。
Nat Genet. 2001 Jan;27(1):79-83. doi: 10.1038/83799.
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Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters.相邻ABC转运蛋白突变导致的谷甾醇血症中膳食胆固醇的蓄积。
Science. 2000 Dec 1;290(5497):1771-5. doi: 10.1126/science.290.5497.1771.