Anderson Jennifer L, Carten Juliana D, Farber Steven A
Carnegie Institution for Science, Department of Embryology, Baltimore, Maryland, USA.
Methods Cell Biol. 2011;101:111-41. doi: 10.1016/B978-0-12-387036-0.00005-0.
Lipids serve essential functions in cells as signaling molecules, membrane components, and sources of energy. Defects in lipid metabolism are implicated in a number of pandemic human diseases, including diabetes, obesity, and hypercholesterolemia. Many aspects of how fatty acids and cholesterol are absorbed and processed by intestinal cells remain unclear and present a hurdle to developing approaches for disease prevention and treatment. Numerous studies have shown that the zebrafish is an excellent model for vertebrate lipid metabolism. In this chapter, we review studies that employ zebrafish to better understand lipid signaling and metabolism.
脂质在细胞中发挥着重要作用，作为信号分子、膜成分和能量来源。脂质代谢缺陷与许多全球性人类疾病有关，包括糖尿病、肥胖症和高胆固醇血症。脂肪酸和胆固醇如何被肠道细胞吸收和处理的许多方面仍不清楚，这对开发疾病预防和治疗方法构成了障碍。大量研究表明，斑马鱼是研究脊椎动物脂质代谢的优秀模型。在本章中，我们回顾了利用斑马鱼来更好地理解脂质信号传导和代谢的研究。
