Barlowe C
Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, USA.
Traffic. 2000 May;1(5):371-7. doi: 10.1034/j.1600-0854.2000.010501.x.
Intracellular transport between the endoplasmic reticulum and Golgi compartments is mediated by coat protein complexes (COPI and COPII) that form transport vesicles and collect the desired set of cargo. Although the COPI and COPII coats are molecularly distinct, a number of mechanistic parallels appear to be emerging, most notably a general role for small guanine triphosphatases in co-ordinating coat assembly with cargo selection. A combination of morphological, biochemical, and genetic methods is revealing a very dynamic relationship between these compartments, and highlights a central role for COPs in directing traffic through the early secretory pathway. This review focuses on recent advances in molecular mechanisms underlying coated-vesicle assembly and connections with cellular structures.
内质网和高尔基体区室之间的细胞内运输由形成运输小泡并收集所需货物组的衣被蛋白复合物（COPI和COPII）介导。尽管COPI和COPII衣被在分子上不同，但一些机制上的相似之处似乎正在显现，最显著的是小GTP酶在协调衣被组装与货物选择方面的普遍作用。形态学、生物化学和遗传学方法的结合揭示了这些区室之间非常动态的关系，并突出了衣被蛋白复合物在指导早期分泌途径运输中的核心作用。本综述重点关注衣被小泡组装的分子机制以及与细胞结构联系的最新进展。
