Ibrahim Hanah A, El-Meligi Amr A, Abdel-Hamid Magdy, Elhendy Abdou
Medical Biochemistry, Internal Medicine and Cardiology Departments, Cairo University Hospital, Cairo, Egypt.
Med Sci Monit. 2004 Mar;10(3):CR85-9. Epub 2004 Mar 1.
to assess the relations among plasma levels of von Willebrand factor (vWf), microalbuminuria and markers of oxidative stress in patients with type 2 diabetes mellitus.
MATERIAL/METHODS: We studied 10 healthy subjects without microalbuminuria or history of coronary artery disease (CAD) and 30 patients with type 2 diabetes mellitus who were classified into three groups, each including 10 patients of matched age and sex; group 1: patients without microalbuminuria or history of CAD; group 2: patients with microalbuminuria and no history of CAD, and group 3: patients with microalbuminuria and history of CAD. All subjects underwent laboratory measurements of vWf, albumin excretion rate (AER), malondialdehyde, vitamin C, reduced glutathione and C peptide.
vWf was elevated in patients with type 2 diabetes mellitus compared with control subjects. However, levels were higher in patients with than without microalbuminuria and in patients with than without a history of CAD (96+/-12, 124+/-7, 149+/-9, 175+/-7 in the control subjects and the diabetic patients' groups respectively). There was a positive correlation between vWf and AER, MDA and C- peptide (r=0.91, 0.98, 0.96, p<0.0001) and a negative correlation between vWf and both vitamin C and reduced glutathione (r=-0.59 and -0.62 respectively, p<0.001).
vWf levels are elevated in patients with type 2 diabetes mellitus, particularly in the presence of microalbuminuria and history of CAD. vWf levels are associated with markers of increased oxidative stress and therefore reflect the severity of biochemical abnormalities, which contribute to diabetic vascular disease.
评估2型糖尿病患者血浆血管性血友病因子（vWf）水平、微量白蛋白尿与氧化应激标志物之间的关系。
材料/方法：我们研究了10名无微量白蛋白尿或冠心病（CAD）病史的健康受试者以及30名2型糖尿病患者，这些患者被分为三组，每组包括10名年龄和性别匹配的患者；第1组：无微量白蛋白尿或CAD病史的患者；第2组：有微量白蛋白尿但无CAD病史的患者，第3组：有微量白蛋白尿且有CAD病史的患者。所有受试者均接受了vWf、白蛋白排泄率（AER）、丙二醛、维生素C、还原型谷胱甘肽和C肽的实验室检测。
与对照组相比，2型糖尿病患者的vWf水平升高。然而，有微量白蛋白尿的患者比无微量白蛋白尿的患者水平更高，有CAD病史的患者比无CAD病史的患者水平更高（对照组和糖尿病患者组分别为96±12、124±7、149±9、175±7）。vWf与AER、丙二醛和C肽之间呈正相关（r = 0.91、0.98、0.96，p < 0.0001），vWf与维生素C和还原型谷胱甘肽均呈负相关（分别为r = -0.59和-0.62，p < 0.001）。
2型糖尿病患者的vWf水平升高，尤其是在存在微量白蛋白尿和CAD病史的情况下。vWf水平与氧化应激增加的标志物相关，因此反映了导致糖尿病血管疾病的生化异常的严重程度。
