人外周髓磷脂中编码PMP - 22（PAS - II/SR13/Gas - 3）的cDNA的分离与序列测定
Isolation and sequence determination of cDNA encoding PMP-22 (PAS-II/SR13/Gas-3) of human peripheral myelin.
作者信息
Hayasaka K, Himoro M, Nanao K, Sato W, Miura M, Uyemura K, Takahashi E, Takada G
机构信息
Department of Pediatrics and Dentistry, Akita University School of Medicine, Japan.
出版信息
Biochem Biophys Res Commun. 1992 Jul 31;186(2):827-31. doi: 10.1016/0006-291x(92)90820-b.
A full length cDNA of PMP-22 (PAS-II/SR13/Gas-3) of peripheral myelin has been isolated from a cDNA library of human fetus spinal cord. The clone is 1823 base pairs (bp) in length and contains a 480 bp open reading frame encoding a polypeptide of 160 residues. The deduced amino acid sequence is highly homologous to PMP-22 from bovine (PAS-II), rat (SR13) and mouse (Gas-3).
已从人胎儿脊髓的cDNA文库中分离出外周髓磷脂PMP - 22（PAS - II / SR13 / Gas - 3）的全长cDNA。该克隆长度为1823个碱基对（bp），包含一个480 bp的开放阅读框，编码一个由160个残基组成的多肽。推导的氨基酸序列与来自牛（PAS - II）、大鼠（SR13）和小鼠（Gas - 3）的PMP - 22高度同源。
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