人外周髓磷脂主要结构蛋白编码cDNA的分离与序列测定
Isolation and sequence determination of cDNA encoding the major structural protein of human peripheral myelin.
作者信息
Hayasaka K, Nanao K, Tahara M, Sato W, Takada G, Miura M, Uyemura K
机构信息
Department of Pediatrics, Akita University School of Medicine, Japan.
出版信息
Biochem Biophys Res Commun. 1991 Oct 31;180(2):515-8. doi: 10.1016/s0006-291x(05)81094-0.
PMID:1719967
Abstract
A full length cDNA of the major structural protein of peripheral myelin (P0 protein) has been isolated from a cDNA library of human fetus spinal cord. The clone is 1948 base pairs (bp) in length and contains a 744 bp open reading frame encoding a polypeptide of 248 residues including 29 signal peptide. The deduced amino acid sequence is highly homologous to P0 protein from other species.
摘要
已从人胎儿脊髓的cDNA文库中分离出外周髓磷脂主要结构蛋白（P0蛋白）的全长cDNA。该克隆长度为1948个碱基对（bp），包含一个744 bp的开放阅读框，编码一个由248个氨基酸残基组成的多肽，其中包括29个信号肽。推导的氨基酸序列与其他物种的P0蛋白高度同源。
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