Oikawa S, Kuroki M, Matsuoka Y, Kosaki G, Nakazato H
Suntory Institute for Biomedical Research, Osaka, Japan.
Biochem Biophys Res Commun. 1992 Jul 31;186(2):881-7. doi: 10.1016/0006-291x(92)90828-9.
Homotypic and heterotypic cell adhesion activities of a carcinoembryonic antigen (CEA) family member, biliary glycoprotein a (BGPa), have been examined. CHO cells transfected with the cDNA for BGPa, CEA, non-specific cross-reacting antigen (NCA) and CGM6 have been used. The BGPa producers showed both homotypic and heterotypic adhesion to CEA and NCA producers. However, they hardly adhered to CGM6 producers. Calcium ion was not required for BGPa-mediated homotypic and heterotypic cell adhesion as well as for the adhesions of other members of CEA family. The results strongly suggested that BGPa may play some important roles through Ca(++)-independent cell adhesion activities.
已对癌胚抗原（CEA）家族成员胆汁糖蛋白a（BGPa）的同型和异型细胞黏附活性进行了检测。使用了用BGPa、CEA、非特异性交叉反应抗原（NCA）和CGM6的cDNA转染的CHO细胞。BGPa产生细胞对CEA和NCA产生细胞表现出同型和异型黏附。然而，它们几乎不与CGM6产生细胞黏附。BGPa介导的同型和异型细胞黏附以及CEA家族其他成员的黏附都不需要钙离子。结果强烈表明，BGPa可能通过不依赖Ca(++)的细胞黏附活性发挥一些重要作用。
