Falcetta R, Sacerdote C, Bazzan M, Pollio B, Ciocca Vasino M A, Ciccone G, Vineis P
Servizio di Medicina del Lavoro, Azienda Ospedaliera OIRM Sant Anna, Torino.
G Ital Med Lav Ergon. 2003 Jul-Sep;25 Suppl(3):9-12.
Essential Thrombocythemia (ET) is a chronic myeloproliferative disorder characterized by a long median survival, even though serious complications such as acute hemorrhagic or thrombotic events are not infrequent. Very few information are available about risk factors for ET because of lack of epidemiological studies focused on this topic.
We conducted a case-control study in order to analyze the possible association between ET and some occupational and environmental risk factors. A total of 93 patients enrolled in two hospitals in Turin (Italy) and 280 subjects randomly selected from the general population as controls, were included in the analysis.
We found an association between ET and selected occupations. OR estimates suggest a significant association between ET cooks/waiters (OR 4.96, CI 1.59-16.9) and clerks (OR 2.63, CI 1.53-4.51) and a non significant association between ET and hairdressers (OR 5.10, CI 0.82-31.4), nurses (OR 3.75, CI 0.80-19.4), farmers (OR 1.74, CI 0.84-3.56), electricians (OR 1.42, CI 0.48-3.78), and photographers (OR infinity). Data did not suggest any strong association between environmental risk factors and ET.
Selected occupations seem to be associated to ET. The association of ET with occupations as hairdressers, farmers and electricians could be attributable to known risk factors for other hematolymphopoietic malignancies such as hair dye, pesticides and magnetic fields. The association with other occupations is more difficult to explain, but all the results we presented are consistent with data from previous studies on onco-hematological diseases.
原发性血小板增多症（ET）是一种慢性骨髓增殖性疾病，其特征是中位生存期长，尽管急性出血或血栓形成等严重并发症并不罕见。由于缺乏针对该主题的流行病学研究，关于ET危险因素的信息非常少。
我们进行了一项病例对照研究，以分析ET与一些职业和环境危险因素之间的可能关联。分析纳入了意大利都灵两家医院的93例患者以及从普通人群中随机选取的280名受试者作为对照。
我们发现ET与特定职业之间存在关联。比值比（OR）估计表明，ET与厨师/服务员（OR 4.96，CI 1.59 - 16.9）和职员（OR 2.63，CI 1.53 - 4.51）之间存在显著关联，而ET与美发师（OR 5.10，CI 0.82 - 31.4）、护士（OR 3.75，CI 0.80 - 19.4）、农民（OR 1.74，CI 0.84 - 3.56）、电工（OR 1.42，CI 0.48 - 3.78）和摄影师（OR无穷大）之间无显著关联。数据未表明环境危险因素与ET之间存在任何强关联。
特定职业似乎与ET有关。ET与美发师、农民和电工等职业的关联可能归因于其他血液淋巴系统恶性肿瘤的已知危险因素，如染发剂、农药和磁场。与其他职业的关联更难解释，但我们呈现的所有结果与先前关于肿瘤血液学疾病的研究数据一致。
