Carbone P, Giordano F, Bianca S, Linzalone N, Taruscio D, Mantovani A, Figà-Talamanca I
Dipartimento di Biologia Animale e dell'Uomo, Università degli Studi di Roma La Sapienza.
G Ital Med Lav Ergon. 2003 Jul-Sep;25 Suppl(3):186-7.
The incidence of Congenital Malformations may represent an early biological indicator for human toxicity to environmental and occupational contaminants. SCIENTIFIC OBJECTIVE: We are in the process of exploring the relation between various potential sources of parental periconceptional pregnancy exposures to Endocrine Disrupting Chemicals (EDCs) and selected Congenital Malformations in offspring.
The low incidence of Congenital Malformations leads to an epidemiological "Case-Control" study. The areas of the study are the Ragusa Municipalities and the south-east Siracusa Municipalities. We are conducting personal interviews with parents of about 100 cases with orafacial clefts or male genital malformations and 200 nonmalformed controls. The infants for the study were selected from those born during 1998-2002 in these areas. The more important variables considered are: 1--parental occupation and workplace exposures. 2--relevant confounders and recall bias. The analysis of the data will use the classical approach of case-control study (matching procedure), comparing risk factor frequency between cases and controls.
The results of the study will allow to clarify the relationship between parental exposure to EDCs compounds and human reproduction.
先天性畸形的发生率可能是人类对环境和职业污染物毒性的早期生物学指标。
我们正在探索父母围孕期接触内分泌干扰化学物质（EDCs）的各种潜在来源与后代特定先天性畸形之间的关系。
先天性畸形的低发生率导致了一项流行病学“病例对照”研究。研究区域为拉古萨市和锡拉库扎市东南部。我们正在对约100例患有口面部裂或男性生殖器畸形的病例的父母以及200例无畸形的对照进行个人访谈。研究中的婴儿选自1998年至2002年期间在这些地区出生的婴儿。考虑的更重要变量有：1——父母职业和工作场所接触情况。2——相关混杂因素和回忆偏倚。数据分析将采用病例对照研究的经典方法（匹配程序），比较病例组和对照组之间危险因素的频率。
研究结果将有助于阐明父母接触EDCs化合物与人类生殖之间的关系。
