Davis John K
Department of Medical Humanities, The Brody School of Medicine, East Carolina University, 2S-17 Brody Medical Sciences Building, Greenville, NC 27858-4354, USA.
Account Res. 2003 Jul-Sep;10(3):175-87. doi: 10.1080/714906095.
Except in certain cases of unusual risk, self-experimentation should not be encouraged. It is usually scientifically inadequate for lack of proper controls and sufficient subjects to generate meaningful results. It is also inadequate as an ethical test because even if lay persons are also enrolled, self-experimentation is neither necessary nor sufficient to establish that they may participate. It is not necessary to establish that lay persons may participate because institutional ethics review and informed consent are better ways to determine this. It is not sufficient because the investigator may be more risk accepting or not medically typical. Moreover, because scientific research is now done in teams, self-experimentation may involve undue influence when junior investigators participate as research subjects.
除了某些存在异常风险的情况外，不应鼓励自我实验。由于缺乏适当的对照和足够的受试者以产生有意义的结果，自我实验在科学上通常是不充分的。作为一种伦理测试，它也是不充分的，因为即使纳入了非专业人员，自我实验对于确定他们是否可以参与而言既非必要条件也不充分。确定非专业人员是否可以参与并非必要，因为机构伦理审查和知情同意是确定这一点的更好方式。它也不充分，因为研究者可能更愿意接受风险或并非医学上的典型情况。此外，由于现在科学研究是团队进行的，当初级研究者作为研究对象参与时，自我实验可能会涉及不当影响。
