Dompeling E, Jöbsis Q, Vandevijver N M A, Wesseling G, Hendriks H
Dept of Paediatric Pulmonology, University Hospital Maastricht, The Netherlands.
Eur Respir J. 2004 Feb;23(2):343-6. doi: 10.1183/09031936.04.00100004.
Exposure to sulphur mustard (SM) gas may have extensive immediate effects on the respiratory system. However, long-term effects are far less known. This case report describes a Kurdish male child who was exposed to SM gas during a chemical attack in Iraq at 5 yrs of age. In the acute phase, the child developed severe respiratory symptoms with a chemical pneumonia. Extensive burning of the skin occurred. In the course of 10 yrs, lung function deteriorated progressively to a forced expiratory volume in one second of 30% of predicted value. Severe air-trapping occurred. The lung function abnormalities were not reversed by treatment with corticosteroids or bronchodilators. Infectious exacerbations of the child's lung disease occurred. High resolution computed tomography scan showed multiple bronchiectasis. The histological picture of an open lung biopsy was best described as a "chronic bronchiolitis".
接触硫芥气体会对呼吸系统产生广泛的即时影响。然而，其长期影响却鲜为人知。本病例报告描述了一名库尔德男童，他在5岁时于伊拉克的一次化学袭击中接触了硫芥气体。急性期，该儿童出现严重的呼吸道症状并伴有化学性肺炎。皮肤发生大面积灼伤。在10年的病程中，肺功能逐渐恶化，一秒用力呼气量降至预测值的30%。出现严重的气体潴留。使用皮质类固醇或支气管扩张剂治疗未能逆转肺功能异常。该儿童肺部疾病出现感染性加重。高分辨率计算机断层扫描显示多处支气管扩张。开放性肺活检的组织学表现最符合“慢性细支气管炎”。
