Yeung Chi Keung, Chan Henry Hin Lee
Department of Medicine, University of Hong Kong, Hong Kong.
Am J Clin Dermatol. 2004;5(1):3-8. doi: 10.2165/00128071-200405010-00002.
Acneiform eruption, psoriasis, folliculitis, and maculopapular eruption have been described as adverse reactions to lithium therapy. In controlled studies, patients treated with lithium developed more cutaneous reactions, particularly acne and psoriasis, than patients receiving other psychotropics, with a prevalence in lithium-treated patients as high as 45%. Male patients taking lithium are more susceptible to developing cutaneous reactions than their female counterparts. Lithium tends to worsen or precipitate cutaneous conditions that are characterized by the pathological findings of neutrophilic infiltration. As lithium-related cutaneous adverse effects can be distressing to patients and may affect medication compliance, attention should be paid to skin problems in patients receiving lithium therapy. Management without cessation of lithium therapy is usually feasible except in some patients with psoriasis that is resistant to treatment. Paradoxically, therapeutic effects of topically applied lithium have been noted in seborrheic dermatitis and recurrent herpes infections.
痤疮样皮疹、银屑病、毛囊炎和斑丘疹已被描述为锂盐治疗的不良反应。在对照研究中，接受锂盐治疗的患者比接受其他精神药物治疗的患者出现更多的皮肤反应，尤其是痤疮和银屑病，锂盐治疗患者中的患病率高达45%。服用锂盐的男性患者比女性患者更容易出现皮肤反应。锂盐往往会使以中性粒细胞浸润的病理表现为特征的皮肤状况恶化或引发此类状况。由于锂盐相关的皮肤不良反应可能令患者苦恼并可能影响药物依从性，因此接受锂盐治疗的患者应注意皮肤问题。除了一些对治疗有抵抗性的银屑病患者外，不停止锂盐治疗通常是可行的。矛盾的是，局部应用锂盐在脂溢性皮炎和复发性疱疹感染中已显示出治疗效果。
