Baker Kevin B, Kim Jeansok J
Department of Psychology, Yale University, New Haven, CT, USA.
Behav Neurosci. 2004 Feb;118(1):15-23. doi: 10.1037/0735-7044.118.1.15.
The relative contribution of left and right amygdalae in the acquisition and retention of fear conditioning was investigated in rats. Pretraining bilateral electrolytic lesions blocked the acquisition of conditioned fear to tone and context, whereas unilateral lesions induced partial impairments with no left-right amygdala differences. In contrast, posttraining bilateral and unilateral lesions produced significant deficits in the retention of conditioned fear to tone and context. Although no left-right difference was observed to tone, the right amygdala lesions generated greater deficits in contextual fear than the left amygdala lesions. These results indicate that fear conditioning is partially disrupted with unilateral amygdalar lesions, but that the right amygdala has greater involvement than the left amygdala when conditioning occurs under a normal brain state.
研究了大鼠左右杏仁核在恐惧条件反射的获得和保持中的相对作用。训练前双侧电解损伤会阻碍对音调及环境的条件性恐惧的获得，而单侧损伤会导致部分损伤，且左右杏仁核之间无差异。相比之下，训练后双侧和单侧损伤在对音调及环境的条件性恐惧的保持上产生了显著缺陷。虽然在对音调的反应上未观察到左右差异，但右侧杏仁核损伤比左侧杏仁核损伤在情境性恐惧方面产生了更大的缺陷。这些结果表明，单侧杏仁核损伤会部分破坏恐惧条件反射，但在正常脑状态下进行条件反射时，右侧杏仁核比左侧杏仁核的参与度更高。
