Scicli Andrea P, Petrovich Gorica D, Swanson Larry W, Thompson Richard F
Neuroscience Program, University of Southern California, Los Angeles, CA 90089-2520, USA.
Behav Neurosci. 2004 Feb;118(1):5-14. doi: 10.1037/0735-7044.118.1.5.
Fos, the protein product of the immediate early gene c-fos, was used to map functional circuitry underlying contextual conditioned fear. Male rats were given footshocks in a distinctive context and later tested using freezing as the behavioral measure and compared with no-shock and no-retention-test control groups. An increased number of Fos-immunoreactive neurons was found in the lateral part of the central nucleus and in the anterior basolateral and lateral amygdalar nuclei in the brains of the conditioned-fear group compared with controls. Further, a greater number of Fos-immunoreactive neurons was observed in the right central and anterior basolateral nuclei compared with the number of labeled neurons in these structures on the left.
原癌基因c-fos的蛋白质产物Fos被用于绘制情境性条件恐惧背后的功能回路。雄性大鼠在一个独特的情境中接受足部电击，随后以僵住作为行为指标进行测试，并与无电击和无保留测试的对照组进行比较。与对照组相比，在条件恐惧组大鼠的大脑中，中央核外侧部分、杏仁核前基底外侧核和外侧核中Fos免疫反应性神经元数量增加。此外，与左侧这些结构中标记神经元的数量相比，右侧中央核和前基底外侧核中观察到更多的Fos免疫反应性神经元。
