Buckley Mark J, Charles David P, Browning Philip G F, Gaffan David
Department of Experimental Psychology, University of Oxford, Oxford, United Kingdom.
Behav Neurosci. 2004 Feb;118(1):138-49. doi: 10.1037/0735-7044.118.1.138.
In macaque monkeys (Macaco mulatta), memory for scenes presented on touch screens is fornix dependent. However, scene learning is not a purely spatial task, and existing direct evidence for a fornix role in spatial memory comes exclusively from tasks involving learning about food-reward locations. Here the authors demonstrate that fornix transection impairs learning about spatial stimuli presented on touch screens. Using a new concurrent spatial discrimination learning task, they found that fornix transection did not impair recall of preoperatively learned problems. Relearning, on the other hand, was mildly impaired, and new learning was strongly impaired. New learning of smaller sets of harder problems was also markedly impaired, as was spatial configured learning. This pattern supports a functional specialization according to stimulus domain in the medial temporal lobe.
在猕猴（恒河猴）中，触屏上呈现场景的记忆依赖于穹窿。然而，场景学习并非纯粹的空间任务，且穹窿在空间记忆中发挥作用的现有直接证据仅来自涉及学习食物奖励位置的任务。在此，作者证明穹窿横断会损害对触屏上呈现的空间刺激的学习。通过一项新的并行空间辨别学习任务，他们发现穹窿横断并不损害术前所学问题的回忆。另一方面，重新学习受到轻度损害，而新学习则受到严重损害。对较难问题的较小集合的新学习以及空间构型学习也明显受损。这种模式支持内侧颞叶中根据刺激领域的功能特化。
